High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease.

A new interesting article has been published in Int J Cardiol. 2019 Jul 15;287:1-6. doi: 10.1016/j.ijcard.2019.04.019. Epub 2019 Apr 8. and titled:

High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease.

Authors of this article are:

Cwikiel J, Seljeflot I, Fagerland MW, Wachtell K, Arnesen H, Berge E, Flaa A.

A summary of the article is shown below:

BACKGROUND: Exercise stress test (EST) has a moderate precision for diagnosis of CAD and could potentially obtain improved accuracy if adding a reliable cardiac biomarker to the test.OBJECTIVE: We aimed to investigate resting levels and change in hs-cTnT during EST in patients with and without angiographically significant CAD. Moreover, we intended to explore the additive value of hs-cTnT to EST results in diagnosis of stable CAD. We hypothesized that hs-cTnT would be higher in CAD patients and increase diagnostic precision of EST.METHOD: Patients presenting with symptoms of stable CAD, performed a maximal EST on a bicycle ergometer. Venous blood samples were taken at rest and within 5 min post-exercise. All patients underwent coronary angiography. Significant CAD was defined as having ≥75% stenosis in one or more segments of the coronary arteries.RESULTS: Out of the 297 participants, significant CAD was found in 111 (37%) patients. Patients with significant CAD compared to without, had higher resting levels of hs-cTnT (median 8.1 vs 5.0 ng/L) and no significant difference in exercise-induced change (median 0.5 vs 0.3 ng/L), p < 0.001 and p = 0.086 respectively. Combined resting hs-cTnT with EST had higher predictive value for significant CAD than EST alone, AUC = 0.751 vs. AUC = 0.637. In an adjusted multivariable regression analysis, resting hs-cTnT >6.0 ng/L was predictive for having significant CAD, OR 2.55 (CI 95% 1.40, 4.65 p = 0.002).CONCLUSION: In patients with suspected stable CAD, hs-cTnT has a predictive value alone, as well as added to a diagnostic EST for CAD.Copyright © 2019 Elsevier B.V. All rights reserved.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: Coronary angiography;Coronary artery disease;Exercise stress test;Troponin T.

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