HAMA Interference Kit

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HAMA Interference Kit
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HAMA Interference Kit

Original price was: $1,295.00.Current price is: $695.00.

Catalog #: K2010009
HAMA Interference Kit consists of six serum samples (2 mL each) to be used to test HAMA interference in immunoassays. The kit includes five serum samples (PS1 to PS5) with a HAMA titer ~ 0-250 ng/mL (actual values are lot dependent). The kit also includes a negative serum sample (NS). HAMA titers were established with a cleared HAMA ELISA method.

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SKU: K2010009 Categories: , Tag:

Product Description

4.9/5 - (34 votes)

HAMA Interference Kit

Lot number: Lot dependent
Expiration date: Lot dependent
Package Size: 1 kit, 6 samples (NS and PS1-PS5)
Other names: Human Anti-mouse Antibodies Interference Kit
Keywords Hama interference Testing, Hama Interference Immunoassays, Hama antibody interference, Hama bridging inference
Concentration:  -20°C. Avoid repeated freeze-thaw.

 

About HAMA

Immunoassays rely heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer when samples contain human anti-mouse antibodies (HAMA). Indeed, HAMA are often associated with inaccurate results because they can bind to both capture and detection antibodies and can generate non-specific signals. This so-called HAMA effect is major interference issue. Assessing the tolerance of an immunoassay to HAMA and mitigating it is very important important during research and development.

References

  • Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem. 1996 Apr;29(2):145-8.
  • Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):647-61.
  • Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013 Nov 15;426:79-84.
  • Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 May 30;614:49-55.
  • Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. J S C Med Assoc. 2012 Feb;108(1):12-3.
  • Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 Sep 30;372(1-2):204-8.

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Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
4.9/5 - (34 votes)

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