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Xanthine Oxidase Grade II (Lyophilized powder)

$695.00 $395.00

Catalog #: P2010006 (100 U)

Xanthine oxidase catalyzes the following reaction:

Xanthine + O₂ + H₂O → Uric acid + H₂O₂

Xanthine oxidase uses molybdenum as cofactor and plays a central role in the metabolism of nucleotides. It is extensively used in enzymatic assays for the determination of inorganic phosphorus, 5′-nucleotidase (5’-NT) and adenosine deaminase (ADA).

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SKU: P2010006 Category: Tag:

Description

Xanthine Oxidase Grade II.

Product Data Sheet
Catalog # P2010006
Size 100 U and bulk
Unit Definition Amount of enzyme that produces one micromole of uric acid per minute at pH 7.5 and 25 °C.
Molecular Weight 160 kDa
Specific Activity 16 U/mg
Purity Uricase, phosphatase < 0.001%
Storage -20°C. Avoid repeated freeze/thaw cycles.
Supplied as Brow-red lyophilized powder
Keywords Xanthine oxidase

 

References

  • Xanthine oxidase of Acinetobacter calcoaceticus RL2-M4: Production, purification and characterization. Monika, Sharma NK, Thakur N, Sheetal, Savitri, Bhalla TC. Protein Expr Purif. 2019 Aug;160:36-44.
  • Xanthine Oxidase and its Role as Target in Cardiovascular Disease: Cardiovascular Protection by Enzyme Inhibition? Schuchardt M, Herrmann J, Tolle M, van der Giet M. Curr Pharm Des. 2017;23(23):3391-3404.
  • Xanthine oxidase inhibitory activity of new pyrrole carboxamide derivatives: In vitro and in silico studies. Kıbrız İE, Saçmacı M, Yıldırım İ, Abbas Ali Noma S, Taşkın Tok T, Ateş B. Arch Pharm (Weinheim). 2018 Oct;351(10):e1800165.
  • Design, synthesis and biological evaluation of 1-hydroxy-2-phenyl-4-pyridyl-1H-imidazole derivatives as xanthineoxidase inhibitors. Zhang T, Lv Y, Lei Y, Liu D, Feng Y, Zhao J, Chen S, Meng F, Wang S. Eur J Med Chem. 2018 Feb 25;146:668-677.
  • Novel XanthineOxidase (XO) inhibitory phenylindanes produced by thermal reaction of caffeic acid. Fukuyama Y, Hidaka K, Masuda A, Masuda T. Biosci Biotechnol Biochem. 2018 Oct;82(10):1825-1828.
  • Design, synthesis, and biological evaluation of 5-(4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl)benzonitrile derivatives as xanthineoxidase inhibitors. Zhang TJ, Li SY, Zhang Y, Wu QX, Meng FH. Chem Biol Drug Des. 2018 Feb;91(2):526-533.
  • In-silico Design and ADMET Studies of Natural Compounds as Inhibitors of XanthineOxidase (XO) Enzyme. Malik N, Dhiman P, Khatkar A. Curr Drug Metab. 2017;18(6):577-593.
  • Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate. Yamaguchi Y, Matsumura T, Ichida K, Okamoto K, Nishino T. J Biochem. 2007 Apr;141(4):513-24.