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Rheumatoid Factor (RF) Interference Blocker

Rheumatoid Factor Interference Blocker

$595.00 $395.00

Catalog #: A2010009 (100 mg)

Rheumatoid Factor (RF) interference is a major issue when testing the performance of immunoassays. RF and other autoimmune antibodies present in the serum of Rheumatoid Arthritis patients can, presumably, bridge capture and detection antibodies in a non-specific fashion. This phenomenon leads to the generation of non-specific immunoassay signals and the recovery of higher than expected results as well as false positives. Molecular Depot’s proprietary reagent RF Interference Blocker is a Rheumatoid Factor interference suppressor consisting of a proprietary, highly concentrated, blend of anti-RF antibodies. RF Interference Blocker can be simply spiked into immunoassay reagents to a target concentration of 100-500 ug/mL. Optimal RF Interference Blocker concentration need to be established in an assay-dependent fashion.

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SKU: A2010009 Category: Tags: ,

Description

Rheumatoid Factor Interference Blocker

Product Data Sheet
Catalog # A2010009
Size 100 mg
Other Names RF Blocker
Content Proprietary blend of anti-RF antibodies
Concentration 40 mg/mL
Purity Affinity purified
Storage 2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw.
Supplied as Liquid solution
Buffer Saline
Keywords Rheumatoid Factor, Interference
References 1- Carson DA, Chen PP, Kipps TJ. New roles for rheumatoid factor. J Clin Invest. 1991 Feb;87(2):379-83.

2- Hay FC, Jones MG, Bond A, Soltys AJ. Rheumatoid factors and complex formation. The role of light-chain framework sequences and glycosylation. Clin Orthop Relat Res. 1991 Apr;(265):54-62.

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References

  • Hollander, J. L. (1968). Rheumatoid Arthritis, Rheumatoid Factor, and Gamma G Globulin Fragments. Annals of Internal Medicine, 68(5), 1195.
  • Pappas, D. A., and Bathon, J. M. (2009). Treatment of Rheumatoid Arthritis: Tumor Necrosis Factor Inhibitors. Rheumatoid Arthritis, 337–349.
  • Shingu, M., Ezaki, I., and Nobunaga, M. (1988). Complement-activating properties of immune complexes are suppressed by IgM rheumatoid factor and enhanced by IgG rheumatoid factor. Rheumatology International, 8(3), 95–100.
  • Vaughan, J. H. (1993). Pathogenetic concepts and origins of rheumatoid factor in rheumatoid arthritis. Arthritis and Rheumatism, 36(1), 1–6.

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Material Safety Data Sheet

Ordering Information

1- Order online using our website’s automated shopping/payment system (available 24/7).

2- Order by email: info@moleculardepot.com (available 24/7).

3- Order by Fax: 1-858-437-9884 (available 24/7).

4- Order by phone: 1-858-900-3210 (6 am – 8 pm PST).