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Rheumatoid Factor Interference Blocker

$595.00 $395.00

Catalog #: A2010009 (100 mg)

Rheumatoid Factor (RF) interference is a major issue when testing the performance of immunoassays. RF and other autoimmune antibodies present in the serum of Rheumatoid Arthritis patients can, presumably, bridge capture and detection antibodies in a non-specific fashion. This phenomenon leads to the generation of non-specific immunoassay signals and the recovery of higher than expected results as well as false positives. Molecular Depot’s proprietary reagent RF Interference Blocker is a Rheumatoid Factor interference suppressor consisting of a proprietary, highly concentrated, blend of anti-RF antibodies. RF Interference Blocker can be simply spiked into immunoassay reagents to a target concentration of 100-500 ug/mL. Optimal RF Interference Blocker concentration need to be established in an assay-dependent fashion.

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Description

Rheumatoid Factor Interference Blocker

Product Data Sheet
Catalog # A2010009
Size 100 mg
Other Names RF Blocker
Content Proprietary blend of anti-RF antibodies
Concentration 40 mg/mL
Purity Affinity purified
Storage 2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw.
Supplied as Liquid solution
Buffer Saline
Keywords Rheumatoid Factor, Interference,Rheumatoid factor interference immunoassays, Rheumatoid factor Elisa interference, Rheumatoid factor assay interference, Rheumatoid factor interference, rheumatoid factor interference blockers, rheumatoid factor interference kits
References 1- Carson DA, Chen PP, Kipps TJ. New roles for rheumatoid factor. J Clin Invest. 1991 Feb;87(2):379-83.

2- Hay FC, Jones MG, Bond A, Soltys AJ. Rheumatoid factors and complex formation. The role of light-chain framework sequences and glycosylation. Clin Orthop Relat Res. 1991 Apr;(265):54-62.

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References

  • Hollander, J. L. (1968). Rheumatoid Arthritis, Rheumatoid Factor, and Gamma G Globulin Fragments. Annals of Internal Medicine, 68(5), 1195.
  • Pappas, D. A., and Bathon, J. M. (2009). Treatment of Rheumatoid Arthritis: Tumor Necrosis Factor Inhibitors. Rheumatoid Arthritis, 337–349.
  • Shingu, M., Ezaki, I., and Nobunaga, M. (1988). Complement-activating properties of immune complexes are suppressed by IgM rheumatoid factor and enhanced by IgG rheumatoid factor. Rheumatology International, 8(3), 95–100.
  • Vaughan, J. H. (1993). Pathogenetic concepts and origins of rheumatoid factor in rheumatoid arthritis. Arthritis and Rheumatism, 36(1), 1–6.
  • Xing Q, Fu L, Yu Z, Zhou X. Efficacy and Safety of Integrated Traditional Chinese Medicine and Western Medicine on the Treatment of Rheumatoid Arthritis: A Meta-Analysis. Evid Based Complement Alternat Med. 2020 Apr 2;2020:4348709.
  • Raine C, Austin K, Giles I. Mechanisms determining the amelioration of rheumatoid arthritis in pregnancy: A systematic review. Semin Arthritis Rheum. 2020 Mar 19. pii: S0049-0172(20)30079-2.
  • Toussirot E. The Interrelations between Biological and Targeted Synthetic Agents Used in Inflammatory Joint Diseases, and Obesity or Body Composition. Metabolites. 2020 Mar 13;10(3). pii: E107.
  • Ishikawa Y, Terao C. The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review. Cells. 2020 Feb 19;9(2). pii: E475.

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