Rheumatoid Factor Interference Blocker
$595.00 $395.00
Catalog #: A2010009 (100 mg)
Rheumatoid Factor (RF) interference is a major issue when testing the performance of immunoassays. RF and other autoimmune antibodies present in the serum of Rheumatoid Arthritis patients can, presumably, bridge capture and detection antibodies in a non-specific fashion. This phenomenon leads to the generation of non-specific immunoassay signals and the recovery of higher than expected results as well as false positives. Molecular Depot’s proprietary reagent RF Interference Blocker is a Rheumatoid Factor interference suppressor consisting of a proprietary, highly concentrated, blend of anti-RF antibodies. RF Interference Blocker can be simply spiked into immunoassay reagents to a target concentration of 100-500 ug/mL. Optimal RF Interference Blocker concentration need to be established in an assay-dependent fashion.
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Description
Rheumatoid Factor Interference Blocker
| Product Data Sheet |  |
| Catalog # | A2010009 |
| Size | 100 mg |
| Other Names | RF Blocker |
| Content | Proprietary blend of anti-RF antibodies |
| Concentration | 40 mg/mL |
| Purity | Affinity purified |
| Storage | 2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw. |
| Supplied as | Liquid solution |
| Buffer | Saline |
| Keywords | Rheumatoid Factor, Interference |
| References | 1- Carson DA, Chen PP, Kipps TJ. New roles for rheumatoid factor. J Clin Invest. 1991 Feb;87(2):379-83.
2- Hay FC, Jones MG, Bond A, Soltys AJ. Rheumatoid factors and complex formation. The role of light-chain framework sequences and glycosylation. Clin Orthop Relat Res. 1991 Apr;(265):54-62. |
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References
- Hollander, J. L. (1968). Rheumatoid Arthritis, Rheumatoid Factor, and Gamma G Globulin Fragments. Annals of Internal Medicine, 68(5), 1195.
- Pappas, D. A., and Bathon, J. M. (2009). Treatment of Rheumatoid Arthritis: Tumor Necrosis Factor Inhibitors. Rheumatoid Arthritis, 337–349.
- Shingu, M., Ezaki, I., and Nobunaga, M. (1988). Complement-activating properties of immune complexes are suppressed by IgM rheumatoid factor and enhanced by IgG rheumatoid factor. Rheumatology International, 8(3), 95–100.
- Vaughan, J. H. (1993). Pathogenetic concepts and origins of rheumatoid factor in rheumatoid arthritis. Arthritis and Rheumatism, 36(1), 1–6.
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