CycloScreen: Cyclodextrins Kit for Screening

Description

CycloScreen: Cyclodextrins Kit

Applications

CycloScreen’s cyclodextrins have been proven to be effective in several applications that include:

• protein refolding and stabilization
• small chemicals and reagents stabilization
• quenching of certain detergents
• extension of reagent shelf-life
• specific binding of interfering substances
• transport of chemical compounds

With all three types of cyclodextrins included (α, β and γ as ranked by increasing molecular diameter), the kit offers the option to quickly screen for the most suitable cyclodextrin to a given application. Provided as highly concentrated solutions (5% and 10%), these cyclodextrins can be easily diluted to working concentrations. Working concentrations depend on the application, but typically range from 0.01% to 0.5%. Individual cyclodextrin solutions are available individually and in custom bulk amounts.

References

• • Cyclodextrins in drug carrier systems. Uekama K, Otagiri M. Crit Rev Ther Drug Carrier Syst. 1987;3(1):1-40.
  • Neutron diffraction of alpha, beta and gamma cyclodextrins: hydrogen bonding patterns. Hingerty B, Klar B, Hardgrove GL, Betzel C, Saenger W. J Biomol Struct Dyn. 1984 Aug;2(1):249-60.

  • Inclusion compounds of cyclodextrins. Cramer F, Hettler H. Naturwissenschaften. 1967;54(24):625-32.

  • Analytical applications of enhanced drug luminescence. Baeyens WR, Ling BL. J Pharm Biomed Anal. 1989;7(12):1385-94.

  • Ma Z, Wang N, He H, Tang X. Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. J Control Release. 2019 Dec 28;316:359-380.