Name: HAMA Blocking Reagent (Affinity purified)
Brand: Molecular Depot
SKU: A2010010
Price: 450 USD
Availability: instock
Rating: 4.6 (9 reviews)

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HAMA Blocking Reagent (Affinity purified)

$450.00

Catalog #: A2010010 – 10 mg

The presence in human serum of Human Anti-Mouse antibodies (HAMA) is a major concern in immunoassays. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. The provided HAMA Blocking Reagent specifically binds to HAMA, minimizing their interference and significantly reducing the number of false positives. Simply spike our HAMA Blocking Reagent into your immunoassay reagent(s) to 5-50 ug/mL (optimum concentration is assay dependent).

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In stock

SKU: A2010010 Categories: Antibodies, Interference Tag: MD 1000

Description

HAMA Blocking Reagent

Catalog #	A2010010
Size	10 mg
Other Names	Heterophilic Immunoglobulin Blocking Reagent
Concentration	2 mg/mL
Purity	Affinity purified
Storage	2-8°C (short term). -20°C (long term). Avoid repeated freeze-thaw.
Supplied as	Liquid solution
Buffer	PBS 1x
Keywords	HAMA

About HAMA

For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay development.

References Related to HAMA Blocking Reagent

Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem. 1996 Apr;29(2):145-8.
Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):647-61.
Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013 Nov 15;426:79-84.
Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 May 30;614:49-55.
Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. J S C Med Assoc. 2012 Feb;108(1):12-3.
Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 Sep 30;372(1-2):204-8.