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A new interesting article has been published in J Clin Virol. 2019 Aug;117:80-84. doi: 10.1016/j.jcv.2019.06.007. Epub 2019 Jun 22. and titled:

The new Xpert HCV viral load real-time PCR assay accurately quantifies hepatitis C virus RNA in serum and whole-blood specimens.

Authors of this article are:

Wlassow M, Poiteau L, Roudot-Thoraval F, Rosa I, Soulier A, Hézode C, Ortonne V, Pawlotsky JM, Chevaliez S.

A summary of the article is shown below:

BACKGROUND: Sensitive and accurate hepatitis C virus (HCV) RNA detection and quantification are essential to diagnose and monitor the virological response to antiviral treatment and the emergence of resistance.OBJECTIVE AND STUDY DESIGN: The aim of this study was to assess the ability of the new Xpert HCV Viral Load assay to accurately detect and quantify HCV RNA in serum and in whole blood collected on dried blood spot (DBS). Serum and whole blood from a large series of patients chronically infected with different HCV genotypes were tested in parallel for HCV RNA detection and quantification.RESULTS: A significant relationship between HCV RNA levels measured with the Xpert HCV Viral Load assay and the two commercial real-time PCR comparators (Abbott RealTime HCV test and Cobas AmpliPrep/Cobas Taqman HCV 2.0 test) was found in serum as well as in whole blood specimens.CONCLUSIONS: The Xpert HCV Viral Load assay accurately quantifies HCV RNA regardless of the HCV genotype and can thus confidently be used to detect active HCV infection in serum and in whole blood specimens.Copyright © 2019 Elsevier B.V. All rights reserved.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: Diagnosis;Dried blood spot;HCV RNA;Hepatitis C;Screening.

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