High HAMA K3 EDTA Plasma
Catalog #: S2010006P1
Unique donor K3 EDTA plasma samples with high levels (600 ng/mL to over 10,000 ng/mL) of Human Anti-Mouse Antibodies (HAMA). HAMA titer has been established with an FDA-approved ELISA method. These samples can be used to test HAMA interference in immunoassays. This product is for in vitro research use only. This product is not for diagnostic or therapeutic procedures.
High HAMA K3 EDTA Plasma
|Lot number:||Batch Dependent|
|Expiration date:||Batch Dependent|
|Matrix:||Human K3 EDTA Plasma|
|Storage:||At -20°C or lower. Avoid repeated freeze-thaw cycles. Aliquot as needed.|
|Keywords||HAMA sample, Human Anti-Mouse Antibodies plasma, High HAMA plasma|
For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay development.
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1: Mukherjee S, Ayanambakkam A, Ibrahimi S, Schmidt S, Charkrabarty JH, Khawandanah M. Ibritumomab tiuxetan (Zevalin) and elevated serum human anti-murine antibody (HAMA) Hematol Oncol Stem Cell Ther. 2018 Sep;11(3):187-188.
2: Klee GG. Human anti-mouse antibodies Arch Pathol Lab Med. 2000 Jun;124(6):921-3.
3: Mouser VH, Abbadessa A, Levato R, Hennink WE, Vermonden T, Gawlitta D, Malda J. Development of a thermosensitive HAMA-containing bio-ink for the fabrication of composite cartilage repair constructs Biofabrication. 2017 Mar 23;9(1):015026.
4: Maier W, Buller R, Philipp M, Heuser I. The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders J Affect Disord. 1988 Jan-Feb;14(1):61-8.
5: Imasaka KI, Tomita Y. Reply Ann Thorac Surg. 2018 Oct;106(4):1258-1259.
6: Boulestreau R, Lorthioir A, Persu A, Cremer A, Rubin S, Tharaux PL, Maier B, Mazighi M, Paques M, Bonnin S, Halimi JM, Gosse P. MALIGNANT HYPERTENSION HAMA COHORT: WHERE DO WE STAND IN 2021? J Hypertens. 2022 Jun 1;40(Suppl 1):e283.
7: Xia C, Chen P, Mei S, Ning L, Lei C, Wang J, Zhang J, Ma J, Fan S. Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment Oncotarget. 2017 Jan 10;8(2):2835-2849.
8: Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Schläfke S, Dienel A. Lavender oil preparation Silexan is effective in generalized anxiety disorder–a randomized, double-blind comparison to placebo and paroxetine Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69.
9: Imasaka KI, Tomita Y. Reply Ann Thorac Surg. 2018 Oct;106(4):1264-1265.
10: Matza LS, Morlock R, Sexton C, Malley K, Feltner D. Identifying HAM-A cutoffs for mild, moderate, and severe generalized anxiety disorder Int J Methods Psychiatr Res. 2010 Dec;19(4):223-32.
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