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A new interesting article has been published in Brain Behav. 2019 Dec; 9(12):e01454. doi: 10.1002/brb3.1454. Epub 2019 Oct 24. and titled:

Single-center study of autoimmune encephalitis-related autoantibody testing in Hungary.

Authors of this article are:

Hayden Z, Böröcz K, Csizmadia Z, Balogh P, Kellermayer Z, Bodó K, Najbauer J, Berki T.

A summary of the article is shown below:

OBJECTIVE: Autoantibody detection is crucial for the early diagnosis of autoimmune encephalitis (AIE) since prompt therapy can determine the disease outcome. Here, we report a single-center 6-year retrospective study of autoantibody testing in AIE in the Hungarian population.METHODS: Serum and/or cerebrospinal fluid (CSF) autoantibody tests were performed using cell-based indirect immunofluorescence assay for AIE diagnosis. Samples were provided by neurology clinics as part of a nationwide program. Test results were analyzed for samples received during the period from 2012 to 2018.RESULTS: We tested 1,247 samples from 1,034 patients with suspected AIE. Autoantibodies were present in 60 patients (5.8% of total). The distribution of patients with different autoantibodies by age and sex was as follows: NMDAR (70%), mostly in young females, LGI1 (15%) in middle-aged males, GABAB R (12%) in elderly males, and Caspr2 (7%) in males. Long-term follow-up was conducted in 30 patients with repeated test requests, of which 17 remained positive, and 13 switched to negative.CONCLUSION: We report the most comprehensive clinical laboratory study of autoantibody testing in AIE in the Hungarian population. Our results show that the frequency of different autoantibody types in AIE corresponds to the data described in the literature.© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31650706 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: autoantibodies; autoimmune encephalitis; biochip; laboratory diagnostics.

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