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A new interesting article has been published in Medicine (Baltimore). 2019 Dec; 98(50):e18266. doi: 10.1097/MD.0000000000018266. Case Reports and titled:

Development of myelofibrosis and acute monocytic leukemia in a patient with hereditary spherocytosis: A case report.

Authors of this article are:

Qian J, Shen Q, Yin H, Shi WY, Yang L, Zhang YP, Liu H.

A summary of the article is shown below:

INTRODUCTION: Common symptoms of hereditary spherocytosis (HS) include intermittent jaundice and splenomegaly. Here, we present an unusual clinical course wherein a patient with HS treated with splenectomy developed secondary myelofibrosis and acute monocytic leukemia (M5).PATIENT CONCERNS: After presenting with paleness, fatigue and jaundice, the patient was diagnosed with HS. After splenectomy, follow-up testing, including bone marrow biopsy, revealed myelofibrosis. Subsequently, the patient exhibited blood cell abnormalities consistent with M5.DIAGNOSIS: M5 comorbid with myelofibrosis and a history of HS.INTERVENTIONS: HS was treated with splenectomy. Myelofibrosis was treated with hydroxyurea. The patient refused chemotherapy for M5 and was discharged. He was maintained on hydroxyurea and received periodic blood product transfusions with regular routine blood test monitoring.OUTCOMES: Because of intracranial hemorrhage, the patient died on May 17, 2018, a little >10 months after being diagnosed with leukemia.CONCLUSION: The present patient developed M5 while undergoing treatment for myelofibrosis and after undergoing splenectomy for HS, raising the question of whether these conditions might be associated. Examination of this question will require the analysis of additional cases.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: Biopsy; Follow-Up Studies; Humans; Hydroxyurea; Leukemia, Monocytic, Acute; Male; Middle Aged; Primary Myelofibrosis; Spherocytosis, Hereditary; Splenectomy; Time Factors; Treatment Outcome.

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