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SARS-CoV-2 Spike RBD Gamma Variant

$895.00

Catalog Number: B2010500 (100 ug)
SARS-CoV-2 Spike RBD Gamma Variant is a highly pure recombinant SARS-CoV-2 RBD from the Gamma Variant lineage (P1, with K417N, E484K, N501Y mutations) expressed in HEK293 cells. This product has been used as molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2010500 Categories: ,

Description

SARS-CoV-2 Spike RBD Gamma Variant
Catalog number: B2010500
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 27 kDa
Supplied as: Lyophilized Powder
Applications: molecular component of many serological and antigenic assays for SARS-CoV-2 and its variants
Storage: -20℃
Keywords: Gamma Variant Spike, P1 Spike RBD, P1 RBD
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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U, Kemmer-Brück A, Langer D, Bexon M, Bolte S, Karikó K, Palanche T, Fischer B,
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Cutler M, Kalina W, Kyratsous CA, Cooper D, Dormitzer PR, Jansen KU, Türeci Ö.
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell
responses. Nature. 2020 Oct;586(7830):594-599.

2: Kim S, Liu Y, Lei Z, Dicker J, Cao Y, Zhang XF, Im W. Differential
Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.
bioRxiv [Preprint]. 2021 Jul 26:2021.07.23.453598.

3: Zahradník J, Marciano S, Shemesh M, Zoler E, Harari D, Chiaravalli J, Meyer
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RA, Douek DC, Schreiber G. SARS-CoV-2 variant prediction and antiviral drug
design are enabled by RBD in vitro evolution. Nat Microbiol. 2021
Sep;6(9):1188-1198.

4: Choi JA, Goo J, Yang E, Jung DI, Lee S, Rho S, Jeong Y, Park YS, Park H, Moon
YH, Park U, Seo SH, Lee H, Lee JM, Cho NH, Song M, Kim JO. Cross-Protection
against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein. J
Virol. 2020 Nov 23;94(24):e01176-20.

5: Mohammadi M, Shayestehpour M, Mirzaei H. The impact of spike mutated variants
of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit
recombinant vaccines. Braz J Infect Dis. 2021 Aug 17;25(4):101606.

6: Barton MI, MacGowan SA, Kutuzov MA, Dushek O, Barton GJ, van der Merwe PA.
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human
ACE2 receptor on binding affinity and kinetics. Elife. 2021 Aug 26;10:e70658.

7: Aleem A, Akbar Samad AB, Slenker AK. Emerging Variants of SARS-CoV-2 And
Novel Therapeutics Against Coronavirus (COVID-19). 2021 Jul 18. In: StatPearls
[Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.

8: Chen L, Zody MC, Di Germanio C, Martinelli R, Mediavilla JR, Cunningham MH,
Composto K, Chow KF, Kordalewska M, Corvelo A, Oschwald DM, Fennessey S,
Zetkulic M, Dar S, Kramer Y, Mathema B, Germer S, Stone M, Simmons G, Busch MP,
Maniatis T, Perlin DS, Kreiswirth BN. Emergence of Multiple SARS-CoV-2 Antibody
Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma
Treatment. mSphere. 2021 Aug 25;6(4):e0048021.

9: Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P. N501Y
mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor
ACE2. Elife. 2021 Aug 20;10:e69091.
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Mutations to Antibody Therapies. J Mol Biol. 2021 Sep 3;433(18):167155.

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