Jacaric Acid Methyl Ester

Product Description

Jacaric Acid Methyl Ester
Catalog number: B2012828
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 292.5 g/mol
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Methyl jacarate, Methyl 8(Z),10(E),12(Z)-Octadecatrienoate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Gasmi J, Thomas Sanderson J. Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study Phytomedicine. 2013 Jun 15;20(8-9):734-42.
2: Liu WN, Leung KN. Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis Cancer Cell Int. 2015 Sep 29;15:90.
3: Liu WN, Leung KN. The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages PLoS One. 2015 Dec 2;10(12):e0143684.
4: Shinohara N, Ito J, Tsuduki T, Honma T, Kijima R, Sugawara S, Arai T, Yamasaki M, Ikezaki A, Yokoyama M, Nishiyama K, Nakagawa K, Miyazawa T, Ikeda I. jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice J Oleo Sci. 2012;61(8):433-41.
5: Kijima R, Honma T, Ito J, Yamasaki M, Ikezaki A, Motonaga C, Nishiyama K, Tsuduki T. Jacaric acid is rapidly metabolized to conjugated linoleic acid in rats J Oleo Sci. 2013;62(5):305-12.
6: Liu WN, Leung KN. Apoptosis- and differentiation-inducing activities of jacaric acid, a conjugated linolenic acid isomer, on human eosinophilic leukemia EoL-1 cells Oncol Rep. 2014 Nov;32(5):1881-8.
7: Liu WN, Leung KN. Anti-allergic effect of the naturally-occurring conjugated linolenic acid isomer, jacaric acid, on the activated human mast cell line-1 Biomed Rep. 2015 Nov;3(6):839-842.
8: Shinohara N, Tsuduki T, Ito J, Honma T, Kijima R, Sugawara S, Arai T, Yamasaki M, Ikezaki A, Yokoyama M, Nishiyama K, Nakagawa K, Miyazawa T, Ikeda I. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo Biochim Biophys Acta. 2012 Jul;1821(7):980-8.
9: Dhar Dubey KK, Sharma G, Kumar A. Conjugated Linolenic Acids: Implication in Cancer J Agric Food Chem. 2019 Jun 5;67(22):6091-6101.
10: Van Nieuwenhove CP, Del Huerto Moyano A, Van Nieuwenhove GA, Molina V, Luna Pizarro P. Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues Lipids. 2022 Jan;57(1):33-44.

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