Mouse Granzyme B (Recombinant)

Product Description

Mouse Granzyme B
Catalog number: B2010364
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Mouse Granzyme B expressed in CHO. This protein acts as a protein that plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and iextracellular matrix remodeling.
Storage: -20C
Keywords: rMuGranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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Boland G, Mahmood U. Granzyme B PET Imaging as a Predictive Biomarker of
Immunotherapy Response. Cancer Res. 2017 May 1;77(9):2318-2327.

2: Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ.
Granzyme B and perforin are important for regulatory T cell-mediated suppression
of tumor clearance. Immunity. 2007 Oct;27(4):635-46.

3: Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen
L, Han W, Shen L, Ding J, Shao F. Granzyme A from cytotoxic lymphocytes cleaves
GSDMB to trigger pyroptosis in target cells. Science. 2020 May
29;368(6494):eaaz7548.

4: Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok
TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses
tumour growth by activating anti-tumour immunity. Nature. 2020
Mar;579(7799):415-420.

5: Capaccione KM, Doubrovin M, Bhatt N, Mintz A, Molotkov A. Granzyme B PET
Imaging of the Innate Immune Response. Molecules. 2020 Jul 7;25(13):3102.

6: Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P, Lin
JX, Konieczny BT, Im SJ, Freeman GJ, Leonard WJ, Kissick HT, Ahmed R.
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature
Emerge from PD-1⁺ Stem-like CD8⁺ T Cells during Chronic
Infection. Immunity. 2019 Dec 17;51(6):1043-1058.e4.

7: Sutton VR, Andoniou C, Leeming MG, House CM, Watt SV, Verschoor S, Ciccone A,
Voskoboinik I, Degli-Esposti M, Trapani JA. Differential cleavage of viral
polypeptides by allotypic variants of granzyme B skews immunity to mouse
cytomegalovirus. Biochim Biophys Acta Proteins Proteom. 2020 Sep;1868(9):140457.

8: Qian Q, Chowdhury BP, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal
diesel particle exposure promotes offspring asthma through NK cell-derived
granzyme B. J Clin Invest. 2020 Aug 3;130(8):4133-4151.

9: Galassi C, Manic G, Musella M, Sistigu A, Vitale I. Assessment of IFN-γ and
granzyme-B production by in “sitro” technology. Methods Enzymol.
2020;631:391-414.
10: Casciola-Rosen L, Garcia-Calvo M, Bull HG, Becker JW, Hines T, Thornberry
NA, Rosen A. Mouse and human granzyme B have distinct tetrapeptide specificities
and abilities to recruit the bid pathway. J Biol Chem. 2007 Feb
16;282(7):4545-4552.

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