Ubiquitin Aldehyde

Description

Ubiquitin Aldehyde
Catalog number: MDP0254
CAS Number: 30892-86-5
Sequence: Met*-Gln-Ile-Phe-Val-Lys-Thr-Leu-Thr-Gly-Lys-Thr-Ile-Thr-Leu-Glu-Val-Glu-Pro-Ser-Asp-Thr-Ile-Glu-Asn-Val-Lys-Ala-Lys-Ile-Gln-Asp-Lys-Glu-Gly-Ile-Pro-Pro-Asp-Gln-Gln-Arg-Leu-Ile-Phe-Ala-Gly-Lys-Gln-Leu-Glu-Asp-Gly-Arg-Thr-Leu-Ser-Asp-Tyr-Asn-Ile-Gln-Lys-Glu-Ser-Thr-Leu-His-Leu-Val-Leu-Arg-Leu-Arg-Gly-Gly-H (aldehyde)* Met at position 1 is oxidized to Met(O).
Amount: 50 ug
Molecular Weight: 8564.4 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Fan Z, Wu C, Chen M, Jiang Y, Wu Y, Mao R, Fan Y. The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation Acta Pharm Sin B. 2022 Mar;12(3):1041-1053.
2: Zhang JL, Du BB, Zhang DH, Li H, Kong LY, Fan GJ, Li YP, Li PC, Liang C, Wang Z, Yang LL, Hao ZY, Wu LM, Huang Z, Dong JZ, Zhang JY, Yao R, Wang SJ, Zhang YZ. OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling pathways Hepatology. 2022 May;75(5):1218-1234.
3: Wiener R, Zhang X, Wang T, Wolberger C. The mechanism of OTUB1-mediated inhibition of ubiquitination Nature. 2012 Feb 22;483(7391):618-22.
4: Liao Y, Yang M, Wang K, Wang Y, Zhong B, Jiang N. Deubiquitinating enzyme OTUB1 in immunity and cancer: Good player or bad actor? Cancer Lett. 2022 Feb 1;526:248-258.
5: Ye D, Wang S, Wang X, Lin Y, Huang Y, Chi P. Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway Bioengineered. 2022 Apr;13(4):9106-9116.
6: Hershko A, Rose IA. Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes Proc Natl Acad Sci U S A. 1987 Apr;84(7):1829-33.
7: Chen S, Bu D, Zhu J, Yue T, Guo S, Wang X, Pan Y, Liu Y, Wang P. Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells Neoplasia. 2021 May;23(5):461-472.
8: Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D. The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13 Cell Mol Immunol. 2021 Jun;18(6):1512-1527.
9: Shaeffer JR, Cohen RE. Differential effects of ubiquitin aldehyde on ubiquitin and ATP-dependent protein degradation Biochemistry. 1996 Aug 20;35(33):10886-93.
10: Pei HZ, Huang B, Chang HW, Baek SH. Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability Cell Signal. 2019 Jul;59:85-95.

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