DNA Ligase (ATP-Dependent)


Catalog Number: B2012507 (0.1 mg)
DNA Ligase (ATP-Dependent) is a high quality enzyme that catalyzes the formation of phosphodiester bonds between two DNA fragments. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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DNA Ligase (ATP-Dependent)
Catalog number: B2012507
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.1 mg
Molecular Weight or Concentration: 0 g/mol
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: DNA Ligase, ATP-dependent
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Tomkinson AE, Naila T, Khattri Bhandari S. Altered DNA ligase activity in human disease Mutagenesis. 2020 Feb 13;35(1):51-60.
2: Paes Dias M, Tripathi V, van der Heijden I, Cong K, Manolika EM, Bhin J, Gogola E, Galanos P, Annunziato S, Lieftink C, Andújar-Sánchez M, Chakrabarty S, Smith GCM, van de Ven M, Beijersbergen RL, Bartkova J, Rottenberg S, Cantor S, Bartek J, Ray Chaudhuri A, Jonkers J. Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps Mol Cell. 2021 Nov 18;81(22):4692-4708.e9.
3: Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y. eccDNAs are apoptotic products with high innate immunostimulatory activity Nature. 2021 Nov;599(7884):308-314.
4: Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair Mol Cell. 2021 Jul 15;81(14):3018-3030.e5.
5: Gibson DG. Enzymatic assembly of overlapping DNA fragments Methods Enzymol. 2011;498:349-61.
6: Shi K, Bohl TE, Park J, Zasada A, Malik S, Banerjee S, Tran V, Li N, Yin Z, Kurniawan F, Orellana K, Aihara H. T4 DNA ligase structure reveals a prototypical ATP-dependent ligase with a unique mode of sliding clamp interaction Nucleic Acids Res. 2018 Nov 2;46(19):10474-10488.
7: Altmann T, Gennery AR. DNA ligase IV syndrome; a review Orphanet J Rare Dis. 2016 Oct 7;11(1):137.
8: Caracciolo D, Juli G, Riillo C, Coricello A, Vasile F, Pollastri S, Rocca R, Scionti F, Polerà N, Grillone K, Arbitrio M, Staropoli N, Caparello B, Britti D, Loprete G, Costa G, Di Martino MT, Alcaro S, Tagliaferri P, Tassone P. Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin J Transl Med. 2022 Oct 22;20(1):482.
9: Goff NJ, Brenière M, Buehl CJ, de Melo AJ, Huskova H, Ochi T, Blundell TL, Mao W, Yu K, Modesti M, Meek K. Catalytically inactive DNA ligase IV promotes DNA repair in living cells Nucleic Acids Res. 2022 Oct 28;50(19):11058-11071.
10: Chen S, Lee L, Naila T, Fishbain S, Wang A, Tomkinson AE, Lees-Miller SP, He Y. Structural basis of long-range to short-range synaptic transition in NHEJ Nature. 2021 May;593(7858):294-298.

Products Related to DNA Ligase (ATP-Dependent) can be found at Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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