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ACE2 Protein (Human, Highly Pure)

$595.00

Catalog Number: B2010474 (20 ug)
ACE2 Protein (Human, Highly Pure) is a highly pure human ACE2 protein (produced in HEK293 cells). ACE2 is one of the cellular targets of the SARS-CoV-2 virus. Custom bulk orders of this product are available upon request.
Live Enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2010474 Categories: , ,

Description

ACE2 Protein (Human, Highly Pure)
Catalog number: B2010474
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 ug
Molecular Weight or Concentration: 85 kDa
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure human ACE2 protein (produced in HEK293 cells). ACE2 is one of the cellular targets of the SARS-CoV-2 virus.
Storage: -20°C
Keywords: Angiotensin-converting enzyme 2
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hussain M, Jabeen N, Raza F, Shabbir S, Baig AA, Amanullah A, Aziz B.
Structural variations in human ACE2 may influence its binding with SARS-CoV-2
spike protein. J Med Virol. 2020 Sep;92(9):1580-1586.

2: Bader M, Turner AJ, Alenina N. ACE2, a multifunctional protein – from
cardiovascular regulation to COVID-19. Clin Sci (Lond). 2020 Dec
11;134(23):3229-3232.

3: Mercurio I, Tragni V, Busto F, De Grassi A, Pierri CL. Protein structure
analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2
receptor: from conformational changes to novel neutralizing antibodies. Cell Mol
Life Sci. 2021 Feb;78(4):1501-1522.

4: Luan J, Jin X, Lu Y, Zhang L. SARS-CoV-2 spike protein favors ACE2 from
Bovidae and Cricetidae. J Med Virol. 2020 Sep;92(9):1649-1656.

5: Wang Y, Wang Y, Luo W, Huang L, Xiao J, Li F, Qin S, Song X, Wu Y, Zeng Q,
Jin F, Wang Y. A comprehensive investigation of the mRNA and protein level of
ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. Int
J Med Sci. 2020 Jun 18;17(11):1522-1531.

6: Benton DJ, Wrobel AG, Xu P, Roustan C, Martin SR, Rosenthal PB, Skehel JJ,
Gamblin SJ. Receptor binding and priming of the spike protein of SARS-CoV-2 for
membrane fusion. Nature. 2020 Dec;588(7837):327-330.

7: Guo L, Bi W, Wang X, Xu W, Yan R, Zhang Y, Zhao K, Li Y, Zhang M, Cai X,
Jiang S, Xie Y, Zhou Q, Lu L, Dang B. Engineered trimeric ACE2 binds viral spike
protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2
infection. Cell Res. 2021 Jan;31(1):98-100.

8: Singh H, Choudhari R, Nema V, Khan AA. ACE2 and TMPRSS2 polymorphisms in
various diseases with special reference to its impact on COVID-19 disease.
Microb Pathog. 2021 Jan;150:104621.

9: Yamamoto K, Takeshita H, Rakugi H. A_CE2, angiotensin 1-7 and skeletal muscle:
review in the era of COVID-19. Clin Sci (Lond). 2020 Nov 27;134(22):3047-3062.
10: Jiang YP, Zhao XX, Lv HQ, Wen CP. Drug screening and development from the
affinity of S protein of new coronavirus with ACE2. Eur J Clin Microbiol Infect
Dis. 2021 Apr;40(4):715-723.

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