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High HAMA Serum/Plasma (Single Donor)

From: $850.00$595.00

Catalog #: S2010006
Unique donor serum or plasma samples with high levels (600 ng/mL to 2499 ng/mL) of Human Anti-Mouse Antibodies (HAMA). HAMA titer has been established with a validated ELISA method. These samples can be used to test HAMA interference in immunoassays.

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Description

High HAMA Serum

Product Data Sheet Download PDF
MSDS Download PDF
Catalog number: S2010006
Lot number: Batch Dependent
Expiration date: Batch Dependent
Volume: 750 uL
Appearance: Yellow orange
Origin: Human
Matrix: Filtered human serum or plasma
Storage: At -20°C or lower. Avoid repeated freeze-thaw cycles. Aliquot as needed.
Keywords HAMA sample, Human Anti-Mouse Antibodies serum, High HAMA plasma

 

About HAMA

For decades, immunoassays have relied heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer dramatically when patient samples contains human anti-mouse antibodies. Indeed, HAMA are often associated with inaccurate results and false positives because they can bind to both capture and detection antibodies and can generate non-specific immunoassay signals. This so-called HAMA problem is especially noticeable in patients receiving mouse antibodies therapies. Assessing the tolerance of an immunoassay to HAMA is a corner stone in assay validation.

All Interference Products Brochure

Interference Testing Brochure

References

  • Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. Clin Biochem. 1996 Apr;29(2):145-8.
  • Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):647-61.
  • Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. Clin Chim Acta. 2013 Nov 15;426:79-84.
  • Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. Gene. 2017 May 30;614:49-55.
  • Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. J S C Med Assoc. 2012 Feb;108(1):12-3.
  • Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. J Immunol Methods. 2011 Sep 30;372(1-2):204-8.

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