Lipid A Salmonella (Highly Pure)

Product Description

Lipid A (Salmonella, Highly Pure)
Catalog number: MDP0894
Name: 2-Deoxy-6-O-{2-Deoxy-2-[(R)-3-(Dodecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-(Tetradecanoyloxy)Tetradecanoyl]-beta-D-Glucopyranosyl}-2-[(R)-3-(Hexadecanoyloxy)Tetradecanoylamino]-3-O-[(R)-3-Hydroxytetradecanoyl]-alpha-D-Glucopyranose 1,4′-Diphosphate
Other name(s): Lipid A (Salmonella)
Molecular Formula: C₁₁₀H₂₀₈N₂O₂₆P₂
Molecular Mass: 2036.8
CAS #: 100742-61-8
Storage Temperature: -20C

Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

Safety:
User must review the Safety Data Sheet (SDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes.

References:

1: Gao J, Guo Z. Progress in the synthesis and biological evaluation of lipid A
and its derivatives. Med Res Rev. 2018 Mar;38(2):556-601.

2: Wang X, Quinn PJ, Yan A. Kdo2 -lipid A: structural diversity and impact on
immunopharmacology. Biol Rev Camb Philos Soc. 2015 May;90(2):408-27.

3: Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D’Errico G,
Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-
Santamaría S. Chemistry of lipid A: at the heart of innate immunity. Chemistry.
2015 Jan 7;21(2):500-19. doi: 10.1002/chem.201403923. Epub 2014 Oct 29. PMID:
25353096.

4: Verpalen ECJM, Brouwer AJ, Boons GJ. Synthesis of monophosphoryl lipid A
using 2-naphtylmethyl ethers as permanent protecting groups. Carbohydr Res. 2020
Dec;498:108152.

5: Xiao X, Sankaranarayanan K, Khosla C. Biosynthesis and structure-activity
relationships of the lipid a family of glycolipids. Curr Opin Chem Biol. 2017
Oct;40:127-137.

6: Scott AJ, Oyler BL, Goodlett DR, Ernst RK. Lipid A structural modifications
in extreme conditions and identification of unique modifying enzymes to define
the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta
Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450.

7: Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is
anticorrelated with lipid a leaflet affinity. PLoS One. 2020 Nov
30;15(11):e0242907.

8: Fujimoto Y, Adachi Y, Akamatsu M, Fukase Y, Kataoka M, Suda Y, Fukase K,
Kusumoto S. Synthesis of lipid A and its analogues for investigation of the
structural basis for their bioactivity. J Endotoxin Res. 2005;11(6):341-7.

9: Di Lorenzo F, Crisafi F, La Cono V, Yakimov MM, Molinaro A, Silipo A. The
Structure of the Lipid A of Gram-Negative Cold-Adapted Bacteria Isolated from
Antarctic Environments. Mar Drugs. 2020 Nov 26;18(12):592.

10: Cheng R, Fontana F, Xiao J, Liu Z, Figueiredo P, Shahbazi MA, Wang S, Jin J,
Torrieri G, Hirvonen JT, Zhang H, Chen T, Cui W, Lu Y, Santos HA. Recombination
Monophosphoryl Lipid_A-Derived Vacosome for the Development of Preventive Cancer
Vaccines. ACS Appl Mater Interfaces. 2020 Oct 7;12(40):44554-44562.

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