GBA3 Human Recombinant

Product Description

GBA3 Human Recombinant
Catalog number: B2016906
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 55 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: cBGL1, Cytosolic β-Glucosidase, Cytosolic β-Glucosidase-like Protein-1, Klotho-related Protein, KLrP
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Wang L, Seino J, Tomotake H, Funakoshi Y, Hirayama H, Suzuki T. Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3 Biomolecules. 2015 Jul 16;5(3):1499-514.
2: Hayashi Y, Ito M. Klotho-Related Protein KLrP: Structure and Functions Vitam Horm. 2016;101:1-16.
3: Dekker N, Voorn-Brouwer T, Verhoek M, Wennekes T, Narayan RS, Speijer D, Hollak CE, Overkleeft HS, Boot RG, Aerts JM. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation Blood Cells Mol Dis. 2011 Jan 15;46(1):19-26.
4: Jama M, Zhang M, Poile C, Nakas A, Sharkey A, Dzialo J, Dawson A, Kutywayo K, Fennell DA, Hollox EJ. Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways Genes Chromosomes Cancer. 2024 Jan;63(1):e23189.
5: Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase J Am Chem Soc. 2017 Oct 11;139(40):14192-14197.
6: Deen MC, Proceviat C, Shan X, Wu L, Shen DL, Davies GJ, Vocadlo DJ. Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates ACS Chem Biol. 2020 Apr 17;15(4):824-829.
7: Akiyama H, Kobayashi S, Hirabayashi Y, Murakami-Murofushi K. Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1 Biochem Biophys Res Commun. 2013 Nov 29;441(4):838-43.
8: Kallemeijn WW, Li KY, Witte MD, Marques AR, Aten J, Scheij S, Jiang J, Willems LI, Voorn-Brouwer TM, van Roomen CP, Ottenhoff R, Boot RG, van den Elst H, Walvoort MT, Florea BI, Codée JD, van der Marel GA, Aerts JM, Overkleeft HS. Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12529-33.
9: Lopes-Marques M, Serrano C, Cardoso AR, Salazar R, Seixas S, Amorim A, Azevedo L, Prata MJ. GBA3: a polymorphic pseudogene in humans that experienced repeated gene loss during mammalian evolution Sci Rep. 2020 Jul 14;10(1):11565.
10: Kumar A, Rhee M. Transcriptomic networks of gba3 governing specification of the dopaminergic neurons in zebrafish embryos Genes Genomics. 2022 Dec;44(12):1543-1554.

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