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BACE Antibody (Affinity Purified)

$995.00

Catalog Number: B2010587 (100 ug)
BACE Antibody (Affinity Purified) is highly specific to human BACE (beta-Site APP Cleaving Enzyme). This product has been used as molecular tool in the study of BACE. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2010587 Categories: ,

Description

BACE Antibody (Purified)
Catalog number: B2010587
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: na
Supplied as: Purified Antibody
Applications: molecular tool in the study of BACE
Storage: -20C
Keywords: ASP2, BACE1, Beta Secretase, beta-Site APP Cleaving Enzyme
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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Biomed Sci. 2017 Jul 19;24(1):47.

2: Siblerud R, Mutter J, Moore E, Naumann J, Walach H. A Hypothesis and Evidence
That Mercury May be an Etiological Factor in Alzheimer’s Disease. Int J Environ
Res Public Health. 2019 Dec 17;16(24):5152.

3: Meier SR, Syvänen S, Hultqvist G, Fang XT, Roshanbin S, Lannfelt L, Neumann
U, Sehlin D. Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in
Alzheimer Transgenic Mice After BACE-1 Inhibition. J Nucl Med. 2018
Dec;59(12):1885-1891.

4: Panza F, Lozupone M, Solfrizzi V, Sardone R, Piccininni C, Dibello V,
Stallone R, Giannelli G, Bellomo A, Greco A, Daniele A, Seripa D, Logroscino G,
Imbimbo BP. BACE inhibitors in clinical development for the treatment of
Alzheimer’s disease. Expert Rev Neurother. 2018 Nov;18(11):847-857.

5: Luo G, Xu H, Huang Y, Mo D, Song L, Jia B, Wang B, Jin Z, Miao Z. Deposition
of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice. Biomed Res
Int. 2016;2016:8380618.

6: Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D,
Tanghe A, Bohrmann B. Combined treatment with a BACE inhibitor and anti-Aβ
antibody gantenerumab enhances amyloid reduction in APPLondon mice. J Neurosci.
2014 Aug 27;34(35):11621-30.

7: Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J,
Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. J Prev Alzheimers Dis.
2020;7(3):146-151.

8: Janssens J, Hermans B, Vandermeeren M, Barale-Thomas E, Borgers M, Willems R,
Meulders G, Wintmolders C, Van den Bulck D, Bottelbergs A, Ver Donck L, Larsen
P, Moechars D, Edwards W, Mercken M, Van Broeck B. Passive immunotherapy with a
novel antibody against 3pE-modified Aβ demonstrates potential for enhanced
efficacy and favorable safety in combination with BACE inhibitor treatment in
plaque-depositing mice. Neurobiol Dis. 2021 Jul;154:105365.
9: Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V.
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can
Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol
Biol. 2018 May 25;430(11):1566-1576.

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