Human TWEAK Protein (Highly Pure)

Description

Human TWEAK Protein
Catalog number: B2010373
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human TWEAK Protein expressed in CHO. This protein acts as an apoptosis inducer via multiple pathways of cell death in a cell type-specific manner as well as a promoter of proliferation and migration of endothelial cells.
Storage: -20C
Keywords: rHuTWEAK; TNF-related weak inducer of apoptosis; TNFSF12; DR3LG; APO3L
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hu G, Zeng W, Xia Y. TWEAK/Fn14 signaling in tumors. Tumour Biol. 2017
Jun;39(6):1010428317714624.

2: Liu Q, Xiao S, Xia Y. TWEAK/Fn14 Activation Participates in Skin
Inflammation. Mediators Inflamm. 2017;2017:6746870.

3: Croft M, Siegel RM. Beyond TNF: TNF superfamily cytokines as targets for the
treatment of rheumatic diseases. Nat Rev Rheumatol. 2017 Apr;13(4):217-233.

4: Arriens C, Wren JD, Munroe ME, Mohan C. Systemic lupus erythematosus
biomarkers: the challenging quest. Rheumatology (Oxford). 2017 Apr
1;56(suppl_1):i32-i45.

5: Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-
Quintela A, Martínez JA, Moreno-Aliaga MJ, Portillo MP. Role of Omentin, Vaspin,
Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J
Mol Sci. 2017 Aug 15;18(8):1770.

6: Bernardi S, Voltan R, Rimondi E, Melloni E, Milani D, Cervellati C, Gemmati
D, Celeghini C, Secchiero P, Zauli G, Tisato V. TRAIL, OPG, and TWEAK in kidney
disease: biomarkers or therapeutic targets? Clin Sci (Lond). 2019 May
16;133(10):1145-1166.

7: Vincent C, Findlay DM, Welldon KJ, Wijenayaka AR, Zheng TS, Haynes DR,
Fazzalari NL, Evdokiou A, Atkins GJ. Pro-inflammatory cytokines TNF-related weak
inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein
kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. J Bone
Miner Res. 2009 Aug;24(8):1434-49.

8: Meyer T, Amaya M, Desai H, Robles-Carrillo L, Hatfield M, Francis JL,
Amirkhosravi A. Human platelets contain and release TWEAK. Platelets.
2010;21(7):571-4.

9: Martínez-Miguel P, Medrano-Andrés D, Griera-Merino M, Ortiz A, Rodríguez-
Puyol M, Rodríguez-Puyol D, López-Ongil S. Tweak up-regulates endothelin-1
system in mouse and human endothelial cells. Cardiovasc Res. 2017
Feb;113(2):207-221.

10: Poveda J, Sanz AB, Fernandez-Fernandez B, Carrasco S, Ruiz-Ortega M,
Cannata-Ortiz P, Ortiz A, Sanchez-Niño MD. MXRA5 is a TGF-β1-regulated human
protein with anti-inflammatory and anti-fibrotic properties. J Cell Mol Med.
2017 Jan;21(1):154-164.

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