Trypsin from Human Pancreas (High Activity)

Product Description

Trypsin from Human Pancreas (High Activity)
Catalog number: B2013381
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 vial
Molecular Weight or Concentration: 1,000 BAEE units
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Trypsin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Whitcomb DC, Lowe ME. Human pancreatic digestive enzymes Dig Dis Sci. 2007 Jan;52(1):1-17.
2: Saluja A, Dudeja V, Dawra R, Sah RP. Early Intra-Acinar Events in Pathogenesis of Pancreatitis Gastroenterology. 2019 May;156(7):1979-1993.
3: Sahin-Tóth M. Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction Protein Pept Lett. 2005 Jul;12(5):457-64.
4: Pubols MH, Bartelt DC, Greene LJ. Trypsin inhibitor from human pancreas and pancreatic juice J Biol Chem. 1974 Apr 10;249(7):2235-42.
5: Suhaj P, Olejar T, Matej R. PAR2: The Cornerstone of Pancreatic Diseases Physiol Res. 2022 Nov 28;71(5):583-596.
6: Weiss FU, Laemmerhirt F, Aghdassi A, Lerch MM. New horizons in pancreatic genetics Curr Opin Gastroenterol. 2020 Sep;36(5):437-442.
7: Gui F, Zhang Y, Wan J, Zhan X, Yao Y, Li Y, Haddock AN, Shi J, Guo J, Chen J, Zhu X, Edenfield BH, Zhuang L, Hu C, Wang Y, Mukhopadhyay D, Radisky ES, Zhang L, Lugea A, Pandol SJ, Bi Y, Ji B. Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H J Clin Invest. 2020 Jan 2;130(1):189-202.
8: Fukushima K, Kamimura T, Takimoto-Kamimura M. Structure basis 1/2SLPI and porcine pancreas trypsin interaction J Synchrotron Radiat. 2013 Nov;20(Pt 6):943-7.
9: Pesei ZG, Jancsó Z, Demcsák A, Németh BC, Vajda S, Sahin-Tóth M. Preclinical testing of dabigatran in trypsin-dependent pancreatitis JCI Insight. 2022 Nov 8;7(21):e161145.
10: Anderson RA Jr, Beyler SA, Mack SR, Zaneveld LJ. Characterization of a high-molecular-weight form of human acrosin. Comparison with human pancreatic trypsin Biochem J. 1981 Nov 1;199(2):307-16.

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