TAK1-TAB1 Fusion Human Recombinant

Product Description

TAK1-TAB1 Fusion Human Recombinant
Catalog number: B2016845
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 69 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: TAK1: MAP3K7, TGF1a, TGFβ-activated Kinase 1, Mitogen-activated Protein Kinase Kinase Kinase 7, Transforming Growth Factor-β-activated Kinase 1, TGF-β-activated Kinase 1, TAB1: MAP3K7IP1, TAK1-binding Protein 1, TGF-β-activated Kinase 1 and MAP3K7-binding Protein 1, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T. TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways Biochem Biophys Res Commun. 2002 Oct 11;297(5):1277-81.
2: Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction Science. 1996 May 24;272(5265):1179-82.
3: Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S. Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade Nat Cell Biol. 2003 Mar;5(3):224-30.
4: Thiefes A, Wolf A, Doerrie A, Grassl GA, Matsumoto K, Autenrieth I, Bohn E, Sakurai H, Niedenthal R, Resch K, Kracht M. The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway EMBO Rep. 2006 Aug;7(8):838-44.
5: Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B J Biol Chem. 2001 Nov 9;276(45):41661-7.
6: Kamiyama H, Usui T, Sakurai H, Shoji M, Hayashi Y, Kakeya H, Osada H. Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1 Biosci Biotechnol Biochem. 2008 Jul;72(7):1894-900.
7: Xu Y, Zhu B, Zhang R, Tang J, Liu Y, Wang W, Wang Z, Mao Y, Zeng G, Yan J. TAK1 of blunt snout bream promotes NF-κB activation via interaction with TAB1 in response to pathogenic bacteria Fish Shellfish Immunol. 2022 Jan;120:481-496.
8: Cao S, Cheng M, Liu S, Duan X, Li M. [Expressions of TAK1 and TAB1 in esophageal cancer and their correlation with prognosis] Nan Fang Yi Ke Da Xue Xue Bao. 2018 Jul 30;38(7):895-900.
9: Yuan L, Li S, Chen Q, Xia T, Luo D, Li L, Liu S, Guo S, Liu L, Du C, Jia G, Li X, Lu Z, Yang Z, Liu H, Mai H, Tang L. EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma Cell Death Differ. 2022 Aug;29(8):1513-1527.
10: Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo Genes Dev. 2005 Nov 15;19(22):2668-81.

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