R-spondin-1/RSPO1 (Human, Recombinant)

Product Description

R-spondin-1/RSPO1 (Human, Recombinant)
Catalog number: B2010331
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure R-spondin-1/RSPO1 (Human, Recombinant) expressed in CHO. This protein acts as a secreted protein that is involved in the WNT signaling.
Storage: -20C
Keywords: rHuR-spondin-1/RSPO1; Roof plate-specific spondin-1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y,
Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T,
Sato T. Divergent Routes toward Wnt and R-spondin Niche Independency during
Human Gastric Carcinogenesis. Cell. 2018 Aug 9;174(4):856-869.e17.

3: Sigal M, Reinés MDM, Müllerke S, Fischer C, Kapalczynska M, Berger H, Bakker
ERM, Mollenkopf HJ, Rothenberg ME, Wiedenmann B, Sauer S, Meyer TF. R-spondin-3
induces secretory, antimicrobial Lgr5⁺ cells in the stomach. Nat Cell
Biol. 2019 Jul;21(7):812-823.

4: Sigal M, Logan CY, Kapalczynska M, Mollenkopf HJ, Berger H, Wiedenmann B,
Nusse R, Amieva MR, Meyer TF. Stromal R-spondin orchestrates gastric epithelial
stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455.

5: Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT,
Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J,
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Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC,
Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5
intestinal stem-cell self-renewal. Nature. 2017 May 11;545(7653):238-242.

6: Harnack C, Berger H, Antanaviciute A, Vidal R, Sauer S, Simmons A, Meyer TF,
Sigal M. R-spondin 3 promotes stem cell recovery and epithelial regeneration in
the colon. Nat Commun. 2019 Sep 25;10(1):4368.

7: Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J,
Xu S, Zhang Y, Xie D, Cai D, Bai X. Synovial macrophage M1 polarisation
exacerbates experimental osteoarthritis partially through R-spondin-2. Ann Rheum
Dis. 2018 Oct;77(10):1524-1534.
8: Nagano K. R-spondin signaling as a pivotal regulator of tissue development
and homeostasis. Jpn Dent Sci Rev. 2019 Nov;55(1):80-87.

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