Human CDK4 Protein

Product Description

Human CDK4 Protein
Catalog number: B2011909
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 36.1 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CMM3 protein, CDK4, CDK 4 protein, CDK 4, PSK-J3 protein, CDK-4, Cyclin-dependent kinase 4 protein, CDK-4 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Braal CL, Jongbloed EM, Wilting SM, Mathijssen RHJ, Koolen SLW, Jager A. Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences Drugs. 2021 Feb;81(3):317-331.
2: Gao X, Leone GW, Wang H. Cyclin D-CDK4/6 functions in cancer Adv Cancer Res. 2020;148:147-169.
3: Goel S, DeCristo MJ, McAllister SS, Zhao JJ. CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest Trends Cell Biol. 2018 Nov;28(11):911-925.
4: Suski JM, Braun M, Strmiska V, Sicinski P. Targeting cell-cycle machinery in cancer Cancer Cell. 2021 Jun 14;39(6):759-778.
5: Pandey K, An HJ, Kim SK, Lee SA, Kim S, Lim SM, Kim GM, Sohn J, Moon YW. Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review Int J Cancer. 2019 Sep 1;145(5):1179-1188.
6: Álvarez-Fernández M, Malumbres M. Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition Cancer Cell. 2020 Apr 13;37(4):514-529.
7: Goel S, Bergholz JS, Zhao JJ. Targeting CDK4 and CDK6 in cancer Nat Rev Cancer. 2022 Jun;22(6):356-372.
8: Ingham M, Schwartz GK. Cell-Cycle Therapeutics Come of Age J Clin Oncol. 2017 Sep 1;35(25):2949-2959.
9: Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, Li Q, Li J, Zhou H, Xu L, Wang Y, Yang C. CDK4/6 regulate lysosome biogenesis through TFEB/TFE3 J Cell Biol. 2020 Aug 3;219(8):e201911036.
10: Portman N, Alexandrou S, Carson E, Wang S, Lim E, Caldon CE. Overcoming CDK4/6 inhibitor resistance in ER-positive breast cancer Endocr Relat Cancer. 2019 Jan;26(1):R15-R30.

Products Related to Human CDK4 Protein can be found at Proteins