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E-Selectin/CD62E Extracellular Domain

Original price was: $1,795.00.Current price is: $895.00.

Catalog Number: B2016846 (50 µg)
E-Selectin/CD62E Extracellular Domain is a high quality cell adhesion molecule that is expressed on the surface of leukocytes, including lymphocytes. It plays a key role in the immune response by mediating the adhesion of leukocytes to endothelial cells in the blood vessels, allowing them to migrate to sites of inflammation or infection. The extracellular domain of L-Selectin/CD62L refers to the portion of the protein that is located outside the cell membrane. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

E-Selectin/CD62E Extracellular Domain
Catalog number: B2016846
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 60 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: CD62 Antigen-like Family Member E, ELAM1, Endothelial Leukocyte Adhesion Molecule 1, LECAM2, Leukocyte-endothelial Cell Adhesion Molecule 2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kiely JM, Cybulsky MI, Luscinskas FW, Gimbrone MA Jr. Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells Arterioscler Thromb Vasc Biol. 1995 Aug;15(8):1211-8.
2: Bajorath J, Greenfield B, Munro SB, Day AJ, Aruffo A. Identification of CD44 residues important for hyaluronan binding and delineation of the binding site J Biol Chem. 1998 Jan 2;273(1):338-43.
3: Zhao L, Zhang N, He M, Luo P, Tan L. A nanozyme-based competitive electrochemical immunosensor for the determination of E-selectin Mikrochim Acta. 2022 Oct 6;189(11):406.
4: Ribieras AJ, Ortiz YY, Li Y, Huerta CT, Le N, Shao H, Vazquez-Padron RI, Liu ZJ, Velazquez OC. E-Selectin/AAV2/2 Gene Therapy Alters Angiogenesis and Inflammatory Gene Profiles in Mouse Gangrene Model Front Cardiovasc Med. 2022 Jun 16;9:929466.
5: Davies JM, Radford KJ, Begun J, Levesque JP, Winkler IG. Adhesion to E-selectin primes macrophages for activation through AKT and mTOR Immunol Cell Biol. 2021 Jul;99(6):622-639.
6: Pietrzak ER, Savage NW, Walsh LJ. Human gingival keratinocytes express E-selectin (CD62E) Oral Dis. 1996 Mar;2(1):11-7.
7: Kleinhans H, Kaifi JT, Mann O, Reinknecht F, Freitag M, Hansen B, Schurr PG, Izbicki JR, Strate TG. The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-selectin (CD62E) and P-selectin (CD62P) in severe porcine pancreatitis Histol Histopathol. 2009 May;24(5):551-7.
8: Vainerc B, Nielsen OH. Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease Mediators Inflamm. 1994;3(3):215-8.
9: Elangbam CS, Qualls CW Jr, Dahlgren RR. Cell adhesion molecules–update Vet Pathol. 1997 Jan;34(1):61-73.
10: Dixon GL, Heyderman RS, van der Ley P, Klein NJ. High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor Clin Exp Immunol. 2004 Jan;135(1):85-93.

Products Related to E-Selectin/CD62E Extracellular Domain can be found at Proteins

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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