CA-074

Product Description

CA-074
Catalog number: MDP0690
CAS Number: 134381-21-8
Sequence: [(2S,3S)-3-Propylcarbamoyloxirane-2-carbonyl]-L-isoleucyl-L-proline
Amount: 1 mg
Molecular Weight: 383.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O’Donoghue AJ, Hook V. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B Biochemistry. 2022 Feb 15;61(4):228-238.
2: He X, Fan X, Bai B, Lu N, Zhang S, Zhang L. Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis Pharmacol Res. 2021 Mar;165:105447.
3: Guiney SJ, Adlard PA, Lei P, Mawal CH, Bush AI, Finkelstein DI, Ayton S. Fibrillar α-synuclein toxicity depends on functional lysosomes J Biol Chem. 2020 Dec 18;295(51):17497-17513.
4: Rashid Khan M, Fayaz Ahmad S, Nadeem A, Imam F, Al-Harbi NO, Shahnawaz Khan M, Alsahli M, Alhosaini K. Cathepsin-B inhibitor CA-074 attenuates retinopathy and optic neuritis in experimental autoimmune encephalomyelitis induced in SJL/J mice Saudi Pharm J. 2023 Jan;31(1):147-153.
5: Montaser M, Lalmanach G, Mach L. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.
6: Mihalik R, Imre G, Petak I, Szende B, Kopper L. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown Cell Death Differ. 2004 Dec;11(12):1357-60.
7: Huang Y, Chen Z, Gu Q, Gu Z, Wu X, Yu X. CA-074Me inhibits cathepsin-B and alleviates fibrosis after myocardial infarction Panminerva Med. 2021 Sep;63(3):397-398.
8: Tohyama T, Kiyochi H, Narumoto K, Honda K, Kobayashi N, Kanoh M, Saibara T, Katunuma N. Inhibitory effect of cathepsin B inhibitor CA 074 on mouse anti-rat mixed lymphocyte reaction: novel immunosuppressive strategy for indirect xenoantigen recognition Transplant Proc. 2000 Aug;32(5):944-5.
9: Patel N, Nizami S, Song L, Mikami M, Hsu A, Hickernell T, Chandhanayingyong C, Rho S, Compton JT, Caldwell JM, Kaiser PB, Bai H, Lee HG, Fischer CR, Lee FY. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways J Orthop Res. 2015 Oct;33(10):1474-86.
10: Lowry JR, Klegeris A. Emerging roles of microglial cathepsins in neurodegenerative disease Brain Res Bull. 2018 May;139:144-156.

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