RET Extracellular Domain Human Recombinant

Product Description

RET Extracellular Domain Human Recombinant
Catalog number: B2016866
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 77.5 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Cadherin Family Member 12, Cadherin-related Family Member 16, CDHF12, CDHR16, Hydroxyaryl-protein Kinase, MEN2A,
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu Y, Ribeiro OC, Robinson J, Goldman A. Expression and purification of the extracellular domain of wild-type humanRET and the dimeric oncogenic mutant C634R Int J Biol Macromol. 2020 Dec 1;164:1621-1630.
2: Cosma MP, Cardone M, Carlomagno F, Colantuoni V. Mutations in the extracellular domain cause RET loss of function by a dominant negative mechanism Mol Cell Biol. 1998 Jun;18(6):3321-9.
3: Goodman KM, Kjær S, Beuron F, Knowles PP, Nawrotek A, Burns EM, Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ. RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association Cell Rep. 2014 Sep 25;8(6):1894-1904.
4: Pelet A, Geneste O, Edery P, Pasini A, Chappuis S, Atti T, Munnich A, Lenoir G, Lyonnet S, Billaud M. Various mechanisms cause RET-mediated signaling defects in Hirschsprung’s disease J Clin Invest. 1998 Mar 15;101(6):1415-23.
5: Rabes HM. Gene rearrangements in radiation-induced thyroid carcinogenesis Med Pediatr Oncol. 2001 May;36(5):574-82.
6: Arthan D, Hong SK, Park JI. Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells Cancer Lett. 2010 Nov 1;297(1):31-41.
7: Rosti K, Goldman A, Kajander T. Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1 BMC Biochem. 2015 Feb 28;16:8.
8: Edery P, Lyonnet S, Mulligan LM, Pelet A, Dow E, Abel L, Holder S, Nihoul-Fékété C, Ponder BA, Munnich A. Mutations of the RET proto-oncogene in Hirschsprung’s disease Nature. 1994 Jan 27;367(6461):378-80.
9: Kjaer S, Ibáñez CF. Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET J Biol Chem. 2003 Nov 28;278(48):47898-904.
10: Takahashi M, Asai N, Iwashita T, Isomura T, Miyazaki K, Matsuyama M. Characterization of the ret proto-oncogene products expressed in mouse L cells Oncogene. 1993 Nov;8(11):2925-9.

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