Kdo2-Lipid A (KLA)

Product Description

Kdo2-Lipid A (KLA)
Catalog number: B2015418
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2238.72
Supplied as: Solid
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt), KLA, Kdo2-LipidA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sims K, Haynes CA, Kelly S, Allegood JC, Wang E, Momin A, Leipelt M, Reichart D, Glass CK, Sullards MC, Merrill AH Jr. Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy J Biol Chem. 2010 Dec 3;285(49):38568-79.
2: Huang L, Li Y, Cheng Z, Lv Z, Luo S, Xia Y. PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4/MyD88/NF-κB and NLRP3 Pathways Inflammation. 2023 Feb;46(1):115-128.
3: Crittenden CM, Morrison LJ, Fitzpatrick MD, Myers AP, Novelli ET, Rosenberg J, Akin LD, Srinivasa S, Shear JB, Brodbelt JS. Towards mapping electrostatic interactions between Kdo(2)-lipid A and cationic antimicrobial peptides via ultraviolet photodissociation mass spectrometry Analyst. 2018 Jul 23;143(15):3607-3618.
4: Niu Y, Chen SJ, Klauda JB. Simulations of naïve and KLA-activated macrophage plasma membrane models Biochim Biophys Acta Biomembr. 2024 Jan;1866(1):184242.
5: Chen WW, Chao YJ, Chang WH, Chan JF, Hsu YH. Phosphatidylglycerol Incorporates into Cardiolipin to Improve Mitochondrial Activity and Inhibits Inflammation Sci Rep. 2018 Mar 20;8(1):4919.
6: Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass CK, Subramaniam S. A combined omics study on activated macrophages–enhanced role of STATs in apoptosis, immunity and lipid metabolism Bioinformatics. 2013 Nov 1;29(21):2735-43.
7: Tourki B, Black LM, Kain V, Halade GV. Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure Biomed Pharmacother. 2021 Jul;139:111574.
8: Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages J Lipid Res. 2013 Sep;54(9):2525-42.
9: Zhang G, Zhao L, Zhu J, Feng Y, Wu X. Anti-inflammatory activities and glycerophospholipids metabolism in KLA-stimulated RAW 264.7 macrophage cells by diarylheptanoids from the rhizomes of Alpinia officinarum Biomed Chromatogr. 2018 Feb;32(2).
10: B Gowda S, Gowda D, Kain V, Chiba H, Hui SP, Chalfant CE, Parcha V, Arora P, Halade GV. Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts Am J Physiol Heart Circ Physiol. 2021 Sep 1;321(3):H599-H611.

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