GsMTx-4

Product Description

GsMTx-4
Catalog number: MDP0760
CAS Number: 954420-51-0
Sequence: Gly-Cys-Leu-Glu-Phe-Trp-Trp-Lys-Cys-Asn-Pro-Asn-Asp-Asp-Lys-Cys-Cys-Arg-Pro-Lys-Leu-Lys-Cys-Ser-Lys-Leu-Phe-Lys-Leu-Cys-Asn-Phe-Ser-Phe-NH2 (Reported disulfide bonds between Cys2-Cys17, Cys9-Cys23, and Cys16-Cys30)
Amount: 100 ug
Molecular Weight: 4095.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Grotle AK, Huo Y, Harrison ML, Ybarbo KM, Stone AJ. GsMTx-4 normalizes the exercise pressor reflex evoked by intermittent muscle contraction in early stage type 1 diabetic rats Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1738-H1748.
2: Bowman CL, Gottlieb PA, Suchyna TM, Murphy YK, Sachs F. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology Toxicon. 2007 Feb;49(2):249-70.
3: Yang Y, Wang D, Zhang C, Yang W, Li C, Gao Z, Pei K, Li Y. Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation Hum Cell. 2022 Jan;35(1):51-62.
4: Romac JM, Shahid RA, Swain SM, Vigna SR, Liddle RA. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis Nat Commun. 2018 Apr 30;9(1):1715.
5: Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16148-53.
6: He J, Fang B, Shan S, Xie Y, Wang C, Zhang Y, Zhang X, Li Q. Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1 Cell Death Dis. 2021 Mar 1;12(3):226.
7: Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Lee DG, Earm YE, Kim JI. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel Biochem Biophys Res Commun. 2006 Feb 10;340(2):633-8.
8: Zhao W, Wei Z, Xin G, Li Y, Yuan J, Ming Y, Ji C, Sun Q, Li S, Chen X, Fu W, Zhu Y, Niu H, Huang W. Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension J Thromb Haemost. 2021 Dec;19(12):3113-3125.
9: Friedrich EE, Hong Z, Xiong S, Zhong M, Di A, Rehman J, Komarova YA, Malik AB. Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12980-12985.
10: Guo J, Gu D, Zhao T, Zhao Z, Xiong Y, Sun M, Xin C, Zhang Y, Pei L, Sun J. Trends in Piezo Channel Research Over the Past Decade: A Bibliometric Analysis Front Pharmacol. 2021 Apr 15;12:668714.

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