Complement Component 4c

Product Description

Complement Component 4c
Catalog number: B2012214
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: 147 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: C4, Complement C4, C4c
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Press EM, Gagnon J. Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator Biochem J. 1981 Nov 1;199(2):351-7.
2: Law SK, Gagnon J. The primary structure of the fourth component of human complement (C4)-C-terminal peptides Biosci Rep. 1985 Oct-Nov;5(10-11):913-21.
3: Padilla-Docal B, Iglesias-González I, Bu-Coifiu-Fanego R, Socarrás-Hernández CA, Dorta-Contreras AJ. Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis Am J Trop Med Hyg. 2013 Feb;88(2):230-5.
4: Duan S, Sun L, Nie G, Chen J, Zhang C, Zhu H, Huang Z, Qian J, Zhao X, Xing C, Zhang B, Yuan Y. Association of Glomerular Complement C4c Deposition With the Progression of Diabetic Kidney Disease in Patients With Type 2 Diabetes Front Immunol. 2020 Sep 2;11:2073.
5: Ajona D, Remirez A, Sainz C, Bertolo C, Gonzalez A, Varo N, Lozano MD, Zulueta JJ, Mesa-Guzman M, C Martin A, Perez-Palacios R, Perez-Gracia JL, Massion PP, Montuenga LM, Pio R. A model based on the quantification of complement C4c, CYFRA 21-1 and CRP exhibits high specificity for the early diagnosis of lung cancer Transl Res. 2021 Jul;233:77-91.
6: van der Kolk LE, Grillo-López AJ, Baars JW, Hack CE, van Oers MH. Complement activation plays a key role in the side-effects of rituximab treatment Br J Haematol. 2001 Dec;115(4):807-11.
7: Goldstein R, Moulds JM, Sengar DP. A rare complement component C4 restriction fragment length polymorphism in two families with systemic lupus erythematosus J Rheumatol. 1991 Mar;18(3):345-8.
8: Romi F, Kristoffersen EK, Aarli JA, Gilhus NE. The role of complement in myasthenia gravis: serological evidence of complement consumption in vivo J Neuroimmunol. 2005 Jan;158(1-2):191-4.
9: Molenaar ET, Voskuyl AE, Familian A, van Mierlo GJ, Dijkmans BA, Hack CE. Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein Arthritis Rheum. 2001 May;44(5):997-1002.
10: Kenawy HI, Ali YM, Rajakumar K, Lynch NJ, Kadioglu A, Stover CM, Schwaeble WJ. Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections Immunobiology. 2012 Feb;217(2):272-80.

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