BAPTA (Highly Pure)

Product Description

BAPTA (Highly Pure)
Catalog number: B2012304
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 476.4 g/mol
Supplied as: Crystals
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: N,N’-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-glycine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kang KR, Kim J, Ryu B, Lee SG, Oh MS, Baek J, Ren X, Canavero S, Kim CY, Chung HM. BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo CNS Neurosci Ther. 2021 Aug;27(8):919-929.
2: Jing X, Wang Q, Du T, Zhang W, Liu X, Liu Q, Li T, Wang G, Chen F, Cui X. Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration Int J Mol Med. 2021 Oct;48(4):196.
3: Hu H, Mo X, Li X, Fu X, Hou Y. BAPTA-AM dramatically improves maturation and development of bovine oocytes from grade-3 cumulus-oocyte complexes Mol Reprod Dev. 2018 Jan;85(1):38-45.
4: Wu S, Canisso IF, Yang W, Ul Haq I, Liu Q, Han Y, Zeng S. Intracellular calcium chelating agent (BAPTA-AM) aids stallion semen cooling and freezing-thawing Reprod Domest Anim. 2018 Oct;53(5):1235-1242.
5: Li FJ, Tan KS, He CY. BAPTA-AM decreases cellular pH, inhibits acidocalcisome acidification and autophagy in amino acid-starved T. brucei Mol Biochem Parasitol. 2017 Apr;213:26-29.
6: Liu L, Wu N, Wang Y, Zhang X, Xia B, Tang J, Cai J, Zhao Z, Liao Q, Wang J. TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling J Exp Clin Cancer Res. 2019 Feb 28;38(1):106.
7: Furuta A, Tanaka M, Omata W, Nagasawa M, Kojima I, Shibata H. Microtubule disruption with BAPTA and dimethyl BAPTA by a calcium chelation-independent mechanism in 3T3-L1 adipocytes Endocr J. 2009;56(2):235-43.
8: Ducrot A, Tron A, Bofinger R, Sanz Beguer I, Pozzo JL, McClenaghan ND. Photoreversible stretching of a BAPTA chelator marshalling Ca(2+)-binding in aqueous media Beilstein J Org Chem. 2019 Nov 21;15:2801-2811.
9: Sutton MV, McKinley M, Kulasekharan R, Popik VV. Photo-cleavable analog of BAPTA for the fast and efficient release of Ca(2) Chem Commun (Camb). 2017 May 18;53(41):5598-5601.
10: Urbano FJ, Buño W. BAPTA-AM blocks both voltage-gated and Ca2+-activated K+ currents in cultured bovine chromaffin cells Neuroreport. 1998 Oct 26;9(15):3403-7.

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