AKT/PKB/Rac-Protein Kinase Substrate Conjugated to Biotin


Catalog Number: B2011229 (1 mg)

AKT/PKB/Rac-Protein Kinase Substrate Conjugated to Biotin is a high quality peptide (ARKRERTYSFGHHA), substrate for AKT/PKB/Rac-protein kinases. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011229 Categories: ,


AKT/PKB/Rac-Protein Kinase Substrate Conjugated to Biotin

Catalog number: B2011229
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1942.3 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AKT,PKB,Rac-Protein Kinase Substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream Cell. 2007 Jun 29;129(7):1261-74.
2: Risso G, Blaustein M, Pozzi B, Mammi P, Srebrow A. Akt/PKB: one kinase, many modifications Biochem J. 2015 Jun 1;468(2):203-14.
3: Balasuriya N, Davey NE, Johnson JL, Liu H, Biggar KK, Cantley LC, Li SS, O’Donoghue P. Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1) J Biol Chem. 2020 Jun 12;295(24):8120-8134.
4: Ksiezak-Reding H, Pyo HK, Feinstein B, Pasinetti GM. Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro Biochim Biophys Acta. 2003 Nov 20;1639(3):159-68.
5: Thapa N, Horn HT, Anderson RA. Phosphoinositide spatially free AKT/PKB activation to all membrane compartments Adv Biol Regul. 2019 May;72:1-6.
6: Iida M, Harari PM, Wheeler DL, Toulany M. Targeting AKT/PKB to improve treatment outcomes for solid tumors Mutat Res. 2020 Jan-Apr;819-820:111690.
7: Bertacchini J, Beretti F, Cenni V, Guida M, Gibellini F, Mediani L, Marin O, Maraldi NM, de Pol A, Lattanzi G, Cocco L, Marmiroli S. The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression FASEB J. 2013 Jun;27(6):2145-55.
8: Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells J Biol Chem. 2005 Jun 3;280(22):21622-8.
9: Sasaki K, Sato M, Umezawa Y. Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells J Biol Chem. 2003 Aug 15;278(33):30945-51.
10: Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR. Identification of 14-3-3zeta as a protein kinase B/Akt substrate J Biol Chem. 2002 Jun 14;277(24):21639-42.

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