Proteinase 3 (PR3, Highly Pure)

Product Description

Proteinase 3 (PR3, Highly Pure)
Catalog number: B2010443
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 μg
Molecular Weight or Concentration: 29 kDa
Supplied as: Buffered aqueous solution
Appearance: Solution
Applications: highly pure serine protease expressed in the granules of neutrophils and monocytes.
Storage: −20°C
Keywords: Myeloblastin, PR3 Ag, PR-3, P29B, AGP7
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Grzywa R, Lesner A, Korkmaz B, Sieńczyk M. Proteinase 3 phosphonic
inhibitors. Biochimie. 2019 Nov;166:142-149.

2: Korkmaz B, Horwitz MS, Jenne DE, Gauthier F. Neutrophil elastase, proteinase
3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev. 2010
Dec;62(4):726-59.

3: Martin KR, Witko-Sarsat V. Proteinase 3: the odd one out that became an
autoantigen. J Leukoc Biol. 2017 Sep;102(3):689-698.

4: Sharma RK, Lövström B, Gunnarsson I, Malmström V. Proteinase 3 Autoreactivity
in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological
versus clinical features. Scand J Immunol. 2020 Nov;92(5):e12958.

5: Crisford H, Sapey E, Stockley RA. Proteinase 3; a potential target in chronic
obstructive pulmonary disease and other chronic inflammatory diseases. Respir
Res. 2018 Sep 20;19(1):180.

6: Cohen Tervaert JW. Should proteinase_3 and myeloperoxidase anti-neutrophil
cytoplasmic antibody vasculitis be treated differently: part 2. Nephrol Dial
Transplant. 2019 Mar 1;34(3):384-387.

7: Watts RA. Should proteinase_3 and myeloperoxidase anti-neutrophil cytoplasmic
antibody vasculitis be treated differently: part 1. Nephrol Dial Transplant.
2019 Mar 1;34(3):381-383.

8: Witko-Sarsat V, Thieblemont N. Granulomatosis with polyangiitis (Wegener
granulomatosis): A proteinase_3 driven disease? Joint Bone Spine. 2018
Mar;85(2):185-189.

9: Yanai K, Kaku Y, Hirai K, Kaneko S, Minato S, Mutsuyoshi Y, Ishii H, Kitano
T, Shindo M, Miyazawa H, Ito K, Ueda Y, Hiruta M, Ookawara S, Ueda Y, Morishita
Y. Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing
crescentic glomerulonephritis complicated by infectious endocarditis: a case
report. J Med Case Rep. 2019 Dec 5;13(1):356.
10: N’Guessan K, Grzywa R, Seren S, Gabant G, Juliano MA, Moniatte M, van
Dorsselaer A, Bieth JG, Kellenberger C, Gauthier F, Wysocka M, Lesner A,
Sienczyk M, Cadene M, Korkmaz B. Human proteinase 3 resistance to inhibition
extends to alpha-2 macroglobulin. FEBS J. 2020 Sep;287(18):4068-4081.

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