Human Complement Factor H Deficient Serum

Product Description

Human Complement Factor H Deficient Serum
Catalog number: B2015465
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mL
Molecular Weight or Concentration: N/A
Supplied as: Serum
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Complement Factor, H Factor 1, CHF, Factor H, HF, FH, HF 1, HF 2, HF1, HF2, FHL1, FHL 1, Adrenomedullin Binding Protein, Age Related Maculopathy Susceptibility 1, AHUS 1, AHUS1, AMBP 1, AMBP1, ARMD 4, ARMD4, ARMS 1, ARMS1, beta 1 H globulin, beta 1H, beta1H, CFH FH, H Factor 1 (Complement), MGC88246, HUS
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Yang Y, Denton H, Davies OR, Smith-Jackson K, Kerr H, Herbert AP, Barlow PN, Pickering MC, Marchbank KJ. An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy J Am Soc Nephrol. 2018 Jun;29(6):1649-1661.
2: Kamala O, Malik TH, Hallam TM, Cox TE, Yang Y, Vyas F, Luli S, Connelly C, Gibson B, Smith-Jackson K, Denton H, Pappworth IY, Huang L, Kavanagh D, Pickering MC, Marchbank KJ. Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice Front Immunol. 2021 Dec 9;12:752916.
3: Alexander JJ, Hack BK, Jacob A, Chang A, Haas M, Finberg RW, Quigg RJ. Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes J Immunol. 2010 Sep 15;185(6):3759-67.
4: Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G. Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum J Immunol. 2018 Dec 15;201(12):3497-3502.
5: de Boer E, Sokolova M, Quach HQ, McAdam KE, Götz MP, Chaban V, Vaage J, Fageräng B, Woodruff TM, Garred P, Nilsson PH, Mollnes TE, Pischke SE. Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release J Immunol. 2022 Nov 1;209(9):1760-1767.
6: Stoiber H, Pintér C, Siccardi AG, Clivio A, Dierich MP. Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55) J Exp Med. 1996 Jan 1;183(1):307-10.
7: Naked GM, Florido MP, Ferreira de Paula P, Vinet AM, Inostroza JS, Isaac L. Deficiency of human complement factor I associated with lowered factor H Clin Immunol. 2000 Aug;96(2):162-7.
8: Alexander JJ, Wang Y, Chang A, Jacob A, Minto AW, Karmegam M, Haas M, Quigg RJ. Mouse podocyte complement factor H: the functional analog to human complement receptor 1 J Am Soc Nephrol. 2007 Apr;18(4):1157-66.
9: Maillard N, Wyatt RJ, Julian BA, Kiryluk K, Gharavi A, Fremeaux-Bacchi V, Novak J. Current Understanding of the Role of Complement in IgA Nephropathy J Am Soc Nephrol. 2015 Jul;26(7):1503-12.
10: Kerr H, Herbert AP, Makou E, Abramczyk D, Malik TH, Lomax-Browne H, Yang Y, Pappworth IY, Denton H, Richards A, Marchbank KJ, Pickering MC, Barlow PN. Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice Front Immunol. 2021 May 12;12:681098.

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