Human 4E-BP1 Protein

Product Description

Human 4E-BP1 Protein
Catalog number: B2015566
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 14.7 kDa (138 aa)
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: Eukaryotic Translation Initiation Factor 4E-Binding Protein 1, 4E-BP1, eIF4E-Binding Protein 1, Phosphorylated Heat- and Acid-Stable Protein Regulated By Insulin 1, PHAS-I, EIF4EBP1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH, Wang S, Song M, Qu J. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis Protein Cell. 2023 Apr 13;14(3):202-216.
2: She QB. 4E-BP1 as an oncotarget Aging (Albany NY). 2015 Aug;7(8):517-8.
3: Qin X, Jiang B, Zhang Y. 4E-BP1, a multifactor regulated multifunctional protein Cell Cycle. 2016;15(6):781-6.
4: Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I. mTOR coordinates protein synthesis, mitochondrial activity and proliferation Cell Cycle. 2015;14(4):473-80.
5: Zhu HL, Xie SM, Fang M, Zhang JJ, Weng ZP, Zhong XY. 4E-BP1 regulates the sensitivity of human glioma cells to chemotherapy through PI3K/Akt/mTOR-independent pathway Neuropathology. 2014 Jun;34(3):227-35.
6: Wang KY, Wang KJ, Ma Q. The expression and significance of p4E-BP1/4E-BP1 in prostate cancer J Clin Lab Anal. 2022 Apr;36(4):e24332.
7: Maracci C, Motta S, Romagnoli A, Costantino M, Perego P, Di Marino D. The mTOR/4E-BP1/eIF4E Signalling Pathway as a Source of Cancer Drug Targets Curr Med Chem. 2022;29(20):3501-3529.
8: Shuda M, Chang Y, Moore PS. Mitotic 4E-BP1 hyperphosphorylation and cap-dependent translation Cell Cycle. 2015;14(19):3005-6.
9: Hughes JM, Ptushkina M, Karim MM, Koloteva N, von der Haar T, McCarthy JE. Translational repression by human 4E-BP1 in yeast specifically requires human eIF4E as target J Biol Chem. 1999 Feb 5;274(6):3261-4.
10: Savukaitytė A, Gudoitytė G, Bartnykaitė A, Ugenskienė R, Juozaitytė E. siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line Cancer Manag Res. 2021 Feb 5;13:1123-1133.

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