Fluorogenic Caspase 3 Substrate 1

Product Description

Fluorogenic Caspase 3 Substrate 1
Catalog number: B2011257
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 729.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Caspase 3 Substrate, Fluorogenic, Apopain substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Mackay M, Pérez-López AM, Bradley M, Lilienkampf A. Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates Mol Biosyst. 2016 Mar;12(3):693-6.
2: Peterson QP, Goode DR, West DC, Botham RC, Hergenrother PJ. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis Nat Protoc. 2010 Feb;5(2):294-302.
3: Fuente-Garcia C, Sentandreu E, Aldai N, Sentandreu MA. Optimization of a fluorogenic assay to determine caspase 3/7 activity in meat extracts Food Sci Technol Int. 2022 Mar;28(2):128-134.
4: Seol JG, Park WH, Kim ES, Jung CW, Hyun JM, Lee YY, Kim BK. Potential role of caspase-3 and -9 in arsenic trioxide-mediated apoptosis in PCI-1 head and neck cancer cells Int J Oncol. 2001 Feb;18(2):249-55.
5: Fahy RJ, Doseff AI, Wewers MD. Spontaneous human monocyte apoptosis utilizes a caspase-3-dependent pathway that is blocked by endotoxin and is independent of caspase-1 J Immunol. 1999 Aug 15;163(4):1755-62.
6: Li M, Ona VO, Chen M, Kaul M, Tenneti L, Zhang X, Stieg PE, Lipton SA, Friedlander RM. Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury Neuroscience. 2000;99(2):333-42.
7: Mandlekar S, Yu R, Tan TH, Kong AN. Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells Cancer Res. 2000 Nov 1;60(21):5995-6000.
8: Tinsley KW, Cheng SL, Buchman TG, Chang KC, Hui JJ, Swanson PE, Karl IE, Hotchkiss RS. Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis Shock. 2000 Jan;13(1):1-7.
9: Fan J, Cheney PP, Bloch S, Xu B, Liang K, Odonkor CA, Edwards WB, Basak S, Mintz R, Biswas P, Achilefu S. Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3 Curr Anal Chem. 2021;17(8):1182-1193.
10: Sakaue M, Motoyama Y, Yamamoto K, Shiba T, Teshima T, Chiba K. Quantitative measurement of caspase-3 activity in a living starfish egg Biochem Biophys Res Commun. 2006 Dec 1;350(4):878-83.

Products Related to Fluorogenic Caspase 3 Substrate 1 can be found at Substrates