Fluorogenic Elastase Substrate


Catalog Number: B2011110 (1 mg)
Fluorogenic Elastase Substrate is a high quality very sensitive fluorogenic elastase substrate that hydrolyzes to highly fluorescent rhodamine 110 . This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Fluorogenic Elastase Substrate
Catalog number: B2011110
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1167 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Rhodamine Elastase Substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Al-Abdullah IH, Bagramyan K, Bilbao S, Qi M, Kalkum M. Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities Sci Rep. 2017 Mar 13;7:44321.
2: Rust L, Messing CR, Iglewski BH. Elastase assays Methods Enzymol. 1994;235:554-62.
3: Sun Q, Li J, Liu WN, Dong QJ, Yang WC, Yang GF. Non-peptide-based fluorogenic small-molecule probe for elastase Anal Chem. 2013 Dec 3;85(23):11304-11.
4: Lamort AS, Gravier R, Laffitte A, Juliano L, Zani ML, Moreau T. New insights into the substrate specificity of macrophage elastase MMP-12 Biol Chem. 2016 May;397(5):469-84.
5: Johnson AF, Struthers MD, Pierson KB, Mangel WF, Smith LM. Nonisotopic DNA detection system employing elastase and fluorogenic rhodamine substrate Anal Chem. 1993 Sep 1;65(17):2352-9.
6: Rudolphus A, Stolk J, van Twisk C, van Noorden CJ, Dijkman JH, Kramps JA. Detection of extracellular neutrophil elastase in hamster lungs after intratracheal instillation of E. coli lipopolysaccharide using a fluorogenic, elastase-specific, synthetic substrate Am J Pathol. 1992 Jul;141(1):153-60.
7: Liu SY, Xiong H, Li RR, Yang WC, Yang GF. Activity-Based Near-Infrared Fluorogenic Probe for Enabling in Vitro and in Vivo Profiling of Neutrophil Elastase Anal Chem. 2019 Mar 19;91(6):3877-3884.
8: Metzemaekers M, Cambier S, Blanter M, Vandooren J, de Carvalho AC, Malengier-Devlies B, Vanderbeke L, Jacobs C, Coenen S, Martens E, Pörtner N, Vanbrabant L, Van Mol P, Van Herck Y, Van Aerde N, Hermans G, Gunst J, Borin A, Toledo N Pereira B, Dos Sp Gomes AB, Primon Muraro S, Fabiano de Souza G, S Farias A, Proenca-Modena JL, R Vinolo MA; CONTAGIOUS Consortium, Marques PE, Wouters C, Wauters E, Struyf S, Matthys P, Opdenakker G, Marques RE, Wauters J, Gouwy M, Proost P. Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019 Clin Transl Immunology. 2021 Apr 29;10(4):e1271.
9: Anderson BM, Poole DP, Aurelio L, Ng GZ, Fleischmann M, Kasperkiewicz P, Morissette C, Drag M, van Driel IR, Schmidt BL, Vanner SJ, Bunnett NW, Edgington-Mitchell LE. Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease Sci Rep. 2019 Sep 16;9(1):13295.
10: Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7754-9.

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