DIMT1 Protein

Product Description

DIMT1 Protein
Catalog number: B2016699
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 µg
Molecular Weight or Concentration: 62.07 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: DIM1 RRNA Methyltransferase And Ribosome Maturation Factor, HSA9761, Dimethyladenosine transferase
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Shen H, Gonskikh Y, Stoute J, Liu KF. Human DIMT1 generates N(2)(6,6)A-dimethylation-containing small RNAs J Biol Chem. 2021 Oct;297(4):101146.
2: Liberman N, Rothi MH, Gerashchenko MV, Zorbas C, Boulias K, MacWhinnie FG, Ying AK, Flood Taylor A, Al Haddad J, Shibuya H, Roach L, Dong A, Dellacona S, Lafontaine DLJ, Gladyshev VN, Greer EL. 18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis Mol Cell. 2023 Sep 21;83(18):3268-3282.e7.
3: Gonskikh Y, Stoute J, Shen H, Budinich K, Pingul B, Schultz K, Elashal H, Marmorstein R, Shi J, Liu KF. Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia Genes Dev. 2023 Apr 1;37(7-8):321-335.
4: Liu G, Peng X, Cai Y, Cheng A, Zha L, Wang Z. DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma Hum Pathol. 2017 Dec;70:35-42.
5: Verma G, Bowen A, Gheibi S, Hamilton A, Muthukumar S, Cataldo LR, Asplund O, Esguerra J, Karagiannopoulos A, Lyons C, Cowan E, Bellodi C, Prasad R, Fex M, Mulder H. Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion J Biol Chem. 2022 Mar;298(3):101692.
6: Hou X, Tian M, Ning J, Wang Z, Guo F, Zhang W, Hu L, Wei S, Hu C, Yun X, Zhao J, Dong Q, Ruan X, Li D, Gao M, Zheng X. PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause Int J Biol Sci. 2023 Jul 31;19(12):3970-3986.
7: Shen H, Stoute J, Liu KF. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation J Biol Chem. 2020 Aug 21;295(34):12058-12070.
8: Ikeda S, Kitadate A, Abe F, Saitoh H, Michishita Y, Hatano Y, Kawabata Y, Kitabayashi A, Teshima K, Kume M, Takahashi N, Tagawa H. Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic axis in multiple myeloma Cancer Sci. 2017 Apr;108(4):641-652.
9: Guo ZX, Zhou FZ, Song W, Yu LL, Yan WJ, Yin LH, Sang H, Zhang HY. Suppression of microRNA-101 attenuates hypoxia-induced myocardial H9c2 cell injury by targeting DIMT1-Sp1/survivin pathway Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):11986.
10: Guo ZX, Zhou FZ, Song W, Yu LL, Yan WJ, Yin LH, Sang H, Zhang HY. Suppression of microRNA-101 attenuates hypoxia-induced myocardial H9c2 cell injury by targeting DIMT1-Sp1/survivin pathway Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):6965-6976.

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