AGO3 Protein

Product Description

AGO3 Protein
Catalog number: B2016704
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 100.4 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Argonaute 3, RISC Catalytic Component, Eukaryotic Translation Factor 2C, EIF2C3, HAgo3, Argonaute3, EIF-2C, EIF2C
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Park MS, Phan HD, Busch F, Hinckley SH, Brackbill JA, Wysocki VH, Nakanishi K. Human Argonaute3 has slicer activity Nucleic Acids Res. 2017 Nov 16;45(20):11867-11877.
3: Friend K, Campbell ZT, Cooke A, Kroll-Conner P, Wickens MP, Kimble J. A conserved PUF-Ago-eEF1A complex attenuates translation elongation Nat Struct Mol Biol. 2012 Jan 8;19(2):176-83.
4: Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, Lee SW, Peng J, Shi Y. Prolyl 4-hydroxylation regulates Argonaute 2 stability Nature. 2008 Sep 18;455(7211):421-4.
5: Gunawardane LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, Nagami T, Siomi H, Siomi MC. A slicer-mediated mechanism for repeat-associated siRNA 5′ end formation in Drosophila Science. 2007 Mar 16;315(5818):1587-90.
6: Jakymiw A, Ikeda K, Fritzler MJ, Reeves WH, Satoh M, Chan EK. Autoimmune targeting of key components of RNA interference Arthritis Res Ther. 2006;8(4):R87.
7: Turchinovich A, Surowy HM, Tonevitsky AG, Burwinkel B. Interference in transcription of overexpressed genes by promoter-proximal downstream sequences Sci Rep. 2016 Aug 3;6:30735.
8: Schürmann N, Trabuco LG, Bender C, Russell RB, Grimm D. Molecular dissection of human Argonaute proteins by DNA shuffling Nat Struct Mol Biol. 2013 Jul;20(7):818-26.
9: Hauptmann J, Dueck A, Harlander S, Pfaff J, Merkl R, Meister G. Turning catalytically inactive human Argonaute proteins into active slicer enzymes Nat Struct Mol Biol. 2013 Jul;20(7):814-7.
10: van Mierlo JT, Bronkhorst AW, Overheul GJ, Sadanandan SA, Ekström JO, Heestermans M, Hultmark D, Antoniewski C, van Rij RP. Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses PLoS Pathog. 2012;8(8):e1002872.

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