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AGO1 Protein

Original price was: $2,195.00.Current price is: $1,095.00.

Catalog Number: B2016695 (10 µg)
AGO1 Protein is a high quality key component of the RNA-induced silencing complex (RISC), which plays a crucial role in gene regulation by binding to small RNA molecules and targeting specific messenger RNAs for degradation or translational repression. This protein is involved in various cellular processes, including development, stress response, and defense against viruses. Additionally, AGO1 has been studied for its role in RNA interference and microRNA pathways, which are important mechanisms for controlling gene expression. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

AGO1 Protein
Catalog number: B2016695
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 100.2 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Argonaute 1, Argonaute1, RISC Catalytic Component, EIF-2C, EIF2C, EIF2C1, GERP95, Q99
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ghosh S, Liu JL. Genomic Tagging of AGO1 Using CRISPR/Cas9-Mediated Homologous Recombination Methods Mol Biol. 2018;1680:217-235.
2: Stoica C, Carmichael JB, Parker H, Pare J, Hobman TC. Interactions between the RNA interference effector protein Ago1 and 14-3-3 proteins: consequences for cell cycle progression J Biol Chem. 2006 Dec 8;281(49):37646-51.
3: Zofall M, Grewal SI. RNAi-mediated heterochromatin assembly in fission yeast Cold Spring Harb Symp Quant Biol. 2006;71:487-96.
4: Park MS, Phan HD, Busch F, Hinckley SH, Brackbill JA, Wysocki VH, Nakanishi K. Human Argonaute3 has slicer activity Nucleic Acids Res. 2017 Nov 16;45(20):11867-11877.
5: Xu D, Yang H, Zou C, Li WX, Xu Y, Xie C. Identification and functional characterization of the AGO1 ortholog in maize J Integr Plant Biol. 2016 Aug;58(8):749-58.
6: Friend K, Campbell ZT, Cooke A, Kroll-Conner P, Wickens MP, Kimble J. A conserved PUF-Ago-eEF1A complex attenuates translation elongation Nat Struct Mol Biol. 2012 Jan 8;19(2):176-83.
7: Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L. Multivalent Recruitment of Human Argonaute by GW182 Mol Cell. 2017 Aug 17;67(4):646-658.e3.
8: Bellissimo T, Tito C, Ganci F, Sacconi A, Masciarelli S, Di Martino G, Porta N, Cirenza M, Sorci M, De Angelis L, Rosa P, Calogero A, Fatica A, Petrozza V, Fontemaggi G, Blandino G, Fazi F. Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells Cell Death Dis. 2019 Jan 8;10(1):17.
9: Yoshikawa M, Han YW, Fujii H, Aizawa S, Nishino T, Ishikawa M. Cooperative recruitment of RDR6 by SGS3 and SDE5 during small interfering RNA amplification in Arabidopsis Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2102885118.
10: Dunoyer P, Schott G, Himber C, Meyer D, Takeda A, Carrington JC, Voinnet O. RETRACTED: Small RNA duplexes function as mobile silencing signals between plant cells Science. 2010 May 14;328(5980):912-6.

Products Related to AGO1 Protein can be found at Proteins

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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