β-Defensin-1 (Mouse)

Product Description

β-Defensin-1 (Mouse)
Catalog number: MDP0848
CAS Number: 81703-56-2
Sequence: Asp-Gln-Tyr-Lys-Cys-Leu-Gln-His-Gly-Gly-Phe-Cys-Leu-Arg-Ser-Ser-Cys-Pro-Ser-Asn-Thr-Lys-Leu-Gln-Gly-Thr-Cys-Lys-Pro-Asp-Lys-Pro-Asn-Cys-Cys-Lys-Ser (Disulfide bonds between Cys5‐Cys34, Cys12‐Cys27, and Cys17‐Cys35)
Amount: 100 ug
Molecular Weight: 4070.4 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Ryan LK, Diamond G. Modulation of Human β-Defensin-1 Production by Viruses Viruses. 2017 Jun 21;9(6):153.
2: Ryan LK, Dai J, Yin Z, Megjugorac N, Uhlhorn V, Yim S, Schwartz KD, Abrahams JM, Diamond G, Fitzgerald-Bocarsly P. Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity J Leukoc Biol. 2011 Aug;90(2):343-56.
3: Wang Y, Jiang Y, Gong T, Cui X, Li W, Feng Y, Wang B, Jiang Z, Li M. High-level expression and novel antifungal activity of mouse beta defensin-1 mature peptide in Escherichia coli Appl Biochem Biotechnol. 2010 Jan;160(1):213-21.
4: Morrison G, Kilanowski F, Davidson D, Dorin J. Characterization of the mouse beta defensin 1, Defb1, mutant mouse model Infect Immun. 2002 Jun;70(6):3053-60.
5: Ann SJ, Chung JH, Park BH, Kim SH, Jang J, Park S, Kang SM, Lee SH. PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1 Atherosclerosis. 2015 Jun;240(2):389-97.
6: Becknell B, Spencer JD, Carpenter AR, Chen X, Singh A, Ploeger S, Kline J, Ellsworth P, Li B, Proksch E, Schwaderer AL, Hains DS, Justice SS, McHugh KM. Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract PLoS One. 2013 Oct 21;8(10):e77714.
7: Tomalka J, Azodi E, Narra HP, Patel K, O’Neill S, Cardwell C, Hall BA, Wilson JM, Hise AG. β-Defensin 1 plays a role in acute mucosal defense against Candida albicans J Immunol. 2015 Feb 15;194(4):1788-95.
8: Moser C, Weiner DJ, Lysenko E, Bals R, Weiser JN, Wilson JM. beta-Defensin 1 contributes to pulmonary innate immunity in mice Infect Immun. 2002 Jun;70(6):3068-72.
9: Wei C, Tang X, Wang F, Li Y, Sun L, Luo F. Molecular characterization of pulmonary defenses against bacterial invasion in allergic asthma: The role of Foxa2 in regulation of β-defensin 1 PLoS One. 2019 Dec 27;14(12):e0226517.
10: Ahrens K, Schunck M, Podda GF, Meingassner J, Stuetz A, Schröder JM, Harder J, Proksch E. Mechanical and metabolic injury to the skin barrier leads to increased expression of murine β-defensin-1, -3, and -14 J Invest Dermatol. 2011 Feb;131(2):443-52.

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