α-Conotoxin ImI

Product Description

α-Conotoxin ImI
Catalog number: MDP0681
CAS Number: 258338-12-4
Sequence: Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Disulfide bonds between Cys2-Cys8 and Cys3-Cys12)
Amount: 500 ug
Molecular Weight: 1351.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Mei D, Zhao L, Chen B, Zhang X, Wang X, Yu Z, Ni X, Zhang Q. α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer Drug Deliv. 2018 Nov;25(1):493-503.
2: Pereira EF, Alkondon M, McIntosh JM, Albuquerque EX. Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons J Pharmacol Exp Ther. 1996 Sep;278(3):1472-83.
3: Padilla A, Keating P, Hartmann JX, Marí F. Effects of α-conotoxin ImI on TNF-α, IL-8 and TGF-β expression by human macrophage-like cells derived from THP-1 pre-monocytic leukemic cells Sci Rep. 2017 Oct 6;7(1):12742.
4: Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure J Am Chem Soc. 2011 Oct 12;133(40):15866-9.
5: Gehrmann J, Daly NL, Alewood PF, Craik DJ. Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance J Med Chem. 1999 Jul 1;42(13):2364-72.
6: Yu R, Tabassum N, Jiang T. Investigation of α-conotoxin unbinding using umbrella sampling Bioorg Med Chem Lett. 2016 Feb 15;26(4):1296-300.
7: Mei D, Lin Z, Fu J, He B, Gao W, Ma L, Dai W, Zhang H, Wang X, Wang J, Zhang X, Lu W, Zhou D, Zhang Q. The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer Biomaterials. 2015 Feb;42:52-65.
8: Xu X, Liang J, Zhang Z, Jiang T, Yu R. Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations Mar Drugs. 2019 May 23;17(5):303.
9: Broxton NM, Down JG, Gehrmann J, Alewood PF, Satchell DG, Livett BG. Alpha-conotoxin ImI inhibits the alpha-bungarotoxin-resistant nicotinic response in bovine adrenal chromaffin cells J Neurochem. 1999 Apr;72(4):1656-62.
10: Utkin YN, Zhmak MN, Methfessel C, Tsetlin VI. Aromatic substitutions in alpha-conotoxin ImI. Synthesis of iodinated photoactivatable derivative Toxicon. 1999 Dec;37(12):1683-95.

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