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A new interesting article has been published in Ann Vasc Surg. 2019 Jul;58:134-141. doi: 10.1016/j.avsg.2018.09.041. Epub 2019 Jan 24. and titled:

Metabolic Response to Claudication in Peripheral Arterial Disease: A Microdialysis Pilot Study.

Authors of this article are:

McGreevy DT, Dogan S, Oscarsson V, Vergari M, Eliasson K, Hörer TM, Nilsson KF, Norgren L.

A summary of the article is shown below:

OBJECTIVES: This is a pilot study, and the objective of the study was to investigate the possible uses of microdialysis in the calf muscle to assess the metabolic response to intermittent claudication (IC) and in addition evaluate the simultaneous systemic inflammatory reaction.METHODS: Dialysate and venous blood sampling was performed before, during and after walking on a treadmill to maximal tolerable claudication (controls 10 min) using 1 microdialysis catheter inserted in the gastrocnemius muscle, 1 subcutaneously in the pectoral region (as a reference), and a peripheral venous catheter.RESULTS: A total of 9 participants were recruited, 6 patients with IC and 3 healthy control subjects. At baseline, patients with IC and control subjects did not differ in metabolic findings (glucose, lactate, pyruvate, and glycerol) in the gastrocnemius muscle. Subcutaneous glucose concentration was higher in control subjects. After physical exertion, gastrocnemius and subcutaneous glycerol, lactate, and pyruvate concentrations increased in patients with IC. Plasma concentrations of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-1ß (IL-1ß), hepatocyte growth factor, and vascular endothelial growth factor were higher in IC subjects at baseline, and TNF-α, IL-6, and IL-18 increased after walking as did IL-6 and IL-1ß in control subjects. The muscle catheters did not show any signs of harm.CONCLUSIONS: Microdialysis can be used to study the ongoing metabolic response during walking and claudication. Our results suggest both an acute local and a systemic inflammatory reaction during development of claudication.Copyright © 2019 Elsevier Inc. All rights reserved.

Check out the article’s website on Pubmed for more information:

This article is a good source of information and a good way to become familiar with topics such as: Aged;Aged, 80 and over;Biomarkers;Case-Control Studies;Exercise Test;Exercise Tolerance;Feasibility Studies;Female;Humans;Inflammation Mediators;Intermittent Claudication;Leg;Male;Microdialysis;Middle Aged;Muscle, Skeletal;Peripheral Arterial Disease;Pilot Projects;Regional Blood Flow;Time Factors.

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