Human Recombinant Sphingosine Kinase 2

Product Description

Human Recombinant Sphingosine Kinase 2
Catalog number: B2012956
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 ug
Molecular Weight or Concentration: 72.9 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: SK2, SPHK2, SPK2
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hayashi H, Nakagami H, Takami Y, Koriyama H, Mori M, Tamai K, Sun J, Nagao K, Morishita R, Kaneda Y. FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1 Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):909-14.
2: Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S. Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells Mol Cell Biol. 2010 Aug;30(15):3827-41.
3: Pitson SM, Moretti PA, Zebol JR, Lynn HE, Xia P, Vadas MA, Wattenberg BW. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation EMBO J. 2003 Oct 15;22(20):5491-500.
4: Di Pietro P, Carrizzo A, Sommella E, Oliveti M, Iacoviello L, Di Castelnuovo A, Acernese F, Damato A, De Lucia M, Merciai F, Iesu P, Venturini E, Izzo R, Trimarco V, Ciccarelli M, Giugliano G, Carnevale R, Cammisotto V, Migliarino S, Virtuoso N, Strianese A, Izzo V, Campiglia P, Ciaglia E, Levkau B, Puca AA, Vecchione C. Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension J Clin Invest. 2022 Feb 1;132(3):e146343.
5: Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution Gene. 2000 Jun 13;251(1):19-26.
6: Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation J Biol Chem. 2007 Apr 20;282(16):12058-65.
7: El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM. Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation Mol Endocrinol. 2011 Dec;25(12):2144-56.
8: Kharel Y, Raje M, Gao M, Gellett AM, Tomsig JL, Lynch KR, Santos WL. Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate Biochem J. 2012 Oct 1;447(1):149-57.
9: Sukocheva OA, Wang L, Albanese N, Pitson SM, Vadas MA, Xia P. Sphingosine kinase transmits estrogen signaling in human breast cancer cells Mol Endocrinol. 2003 Oct;17(10):2002-12.
10: Simpson PB, Villullas IR, Schurov I, Kerby J, Millard R, Haldon C, Beer MS, McAllister G. Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling Assay Drug Dev Technol. 2002 Nov;1(1 Pt 1):31-40.

Products Related to Human Recombinant Sphingosine Kinase 2 can be found at Proteins