RANTES/CCL5 (Human Recombinant)

Product Description

Human RANTES/CCL5
Catalog number: B2010369
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Human RANTES/CCL5 expressed in HEK 293. This protein acts as a potent CC chemokine, plays an important role in rheumatoid arthritis pathogenesis.
Storage: -20C
Keywords: rHuRANTES/CCL5; C-C motif chemokine 5; SCYA5
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Agere SA, Akhtar N, Watson JM, Ahmed S. RANTES/CCL5 Induces Collagen
Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid
Arthritis Synovial Fibroblasts. Front Immunol. 2017 Oct 18;8:1341.

2: Nosalski R, Guzik TJ. Perivascular adipose tissue inflammation in vascular
disease. Br J Pharmacol. 2017 Oct;174(20):3496-3513.

3: Kim MO, Suh HS, Brosnan CF, Lee SC. Regulation of RANTES/CCL5 expression in
human astrocytes by interleukin-1 and interferon-beta. J Neurochem. 2004
Jul;90(2):297-308.

4: Chatterton DE, Nguyen DN, Bering SB, Sangild PT. Anti-inflammatory mechanisms
of bioactive milk proteins in the intestine of newborns. Int J Biochem Cell
Biol. 2013 Aug;45(8):1730-47.

5: Mustafa M, Wondimu B, Bakhiet M, Modéer T. Production of Rantes/CCL5 in human
gingival fibroblasts challenged with tumor necrosis factor alpha. Eur J Oral
Sci. 2001 Feb;109(1):44-9.

6: Charni F, Friand V, Haddad O, Hlawaty H, Martin L, Vassy R, Oudar O, Gattegno
L, Charnaux N, Sutton A. Syndecan-1 and syndecan-4 are involved in
RANTES/CCL5-induced migration and invasion of human hepatoma cells. Biochim
Biophys Acta. 2009 Oct;1790(10):1314-26.

7: Suffee N, Richard B, Hlawaty H, Oudar O, Charnaux N, Sutton A. Angiogenic
properties of the chemokine RANTES/CCL5. Biochem Soc Trans. 2011
Dec;39(6):1649-53.

8: Funk CJ, Wang J, Ito Y, Travanty EA, Voelker DR, Holmes KV, Mason RJ.
Infection of human alveolar macrophages by human coronavirus strain 229E. J Gen
Virol. 2012 Mar;93(Pt 3):494-503.
9: Skurk T, Mack I, Kempf K, Kolb H, Hauner H, Herder C. Expression and
secretion of RANTES (CCL5) in human adipocytes in response to immunological
stimuli and hypoxia. Horm Metab Res. 2009 Mar;41(3):183-9.

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