Human ALKBH2 Protein

Product Description

Human ALKBH2 Protein
Catalog number: B2011588
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 0.5 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: ALKBH2 protein (His tag), Oxy DC1 protein, ALKBH-2 protein, ALKBH 2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 protein, ALKBH-2, ALKBH 2 protein, ALKBH2, ABH2 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Johannessen TC, Prestegarden L, Grudic A, Hegi ME, Tysnes BB, Bjerkvig R. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells Neuro Oncol. 2013 Mar;15(3):269-78.
2: Fujii T, Shimada K, Anai S, Fujimoto K, Konishi N. ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression Cancer Sci. 2013 Mar;104(3):321-7.
3: Fu D, Samson LD. Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase DNA Repair (Amst). 2012 Jan 2;11(1):46-52.
4: Waheed SO, Ramanan R, Chaturvedi SS, Lehnert N, Schofield CJ, Christov CZ, Karabencheva-Christova TG. Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair ACS Cent Sci. 2020 May 27;6(5):795-814.
5: Ke B, Ye K, Cheng S. ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-κB pathway World J Surg Oncol. 2020 Dec 10;18(1):328.
6: Shaji UP, Tuti N, Das S, Anindya R, Mohan M. Interactions between HIV protease inhibitor ritonavir and human DNA repair enzyme ALKBH2: a molecular dynamics simulation study Mol Divers. 2022 May 11.
7: You C, Wang P, Nay SL, Wang J, Dai X, O’Connor TR, Wang Y. Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions ACS Chem Biol. 2016 May 20;11(5):1332-8.
8: Kaina B, Christmann M. DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas DNA Repair (Amst). 2019 Jun;78:128-141.
9: Yi C, Chen B, Qi B, Zhang W, Jia G, Zhang L, Li CJ, Dinner AR, Yang CG, He C. Duplex interrogation by a direct DNA repair protein in search of base damage Nat Struct Mol Biol. 2012 Jun 3;19(7):671-6.
10: Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions Chem Res Toxicol. 2017 Apr 17;30(4):1102-1110.

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