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Human AKR1C3 Protein (Highly Pure)

$795.00

Catalog Number: B2011565 (100 µg)
Human AKR1C3 Protein (Highly Pure) is a high quality recombinant human AKR1C3 protein His tagged and expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011565 Categories: ,

Description

Human AKR1C3 Protein (Highly Pure)
Catalog number: B2011565
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: AKR1C3 protein (His tag), Purified recombinant Human AKR1C3 protein, HAKRB protein, AKRC3 1, member C3 17 beta HSD 5 protein, DD3 protein, HSD17B5 protein, Prostaglandin F synthase protein, HAKRe protein, AKRC3 1 protein, HA1753 protein, , PGFS protein, Chlordecone reductase protein, AKRC3-1, HSD17B5 protein, AKR1 C3
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma Cancer Res. 2021 Mar 1;81(5):1361-1374.
2: Cho MK. Decreased Expression of Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3) Protein Identified in Human Diabetic Skin Tissue Ann Dermatol. 2013 Nov;25(4):423-7.
3: Liu Y, He S, Chen Y, Liu Y, Feng F, Liu W, Guo Q, Zhao L, Sun H. Overview of AKR1C3: Inhibitor Achievements and Disease Insights J Med Chem. 2020 Oct 22;63(20):11305-11329.
4: Li C, Zhao Y, Zheng X, Zhang H, Zhang L, Chen Y, Li Q, Hu X. In vitro CAPE inhibitory activity towards human AKR1C3 and the molecular basis Chem Biol Interact. 2016 Jun 25;253:60-5.
5: Liu C, Yang JC, Armstrong CM, Lou W, Liu L, Qiu X, Zou B, Lombard AP, D’Abronzo LS, Evans CP, Gao AC. AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer Mol Cancer Ther. 2019 Oct;18(10):1875-1886.
6: Liu J, He P, Lin L, Zhao Y, Deng W, Ding H, Li Q, Wang Z. Characterization of a highly specific monoclonal antibody against human aldo-keto reductase AKR1C3 Steroids. 2019 Mar;143:73-79.
7: Sun SQ, Gu X, Gao XS, Li Y, Yu H, Xiong W, Yu H, Wang W, Li Y, Teng Y, Zhou D. Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation Oncotarget. 2016 Jul 26;7(30):48050-48058.
8: Pan D, Yang W, Zeng Y, Li W, Wang K, Zhao L, Li J, Ye Y, Guo Q. AKR1C3 decreased CML sensitivity to Imatinib in bone marrow microenvironment via dysregulation of miR-379-5p Cell Signal. 2021 Aug;84:110038.
9: Peraldo-Neia C, Ostano P, Mello-Grand M, Guana F, Gregnanin I, Boschi D, Oliaro-Bosso S, Pippione AC, Carenzo A, De Cecco L, Cavalieri S, Micali A, Perrone F, Averono G, Bagnasacco P, Dosdegani R, Masini L, Krengli M, Aluffi-Valletti P, Valente G, Chiorino G. AKR1C3 is a biomarker and druggable target for oropharyngeal tumors Cell Oncol (Dordr). 2021 Apr;44(2):357-372.
10: Wang B, Wu S, Fang Y, Sun G, He D, Hsieh JT, Wang X, Zeng H, Wu K. The AKR1C3/AR-V7 complex maintains CRPC tumour growth by repressing B4GALT1 expression J Cell Mol Med. 2020 Oct;24(20):12032-12043.

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