CREBBP (1075-1873) Protein

Product Description

CREBBP (1075-1873) Protein
Catalog number: B2016672
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 94.3 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: CBP, KAT3A, RSTS
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function Nat Commun. 2021 Nov 3;12(1):6340.
2: Gao C, Liu SG, Lu WT, Yue ZX, Zhao XX, Xing TY, Chen ZP, Zheng HY, Li ZG. Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells Mol Med Rep. 2020 Oct;22(4):2905-2915.
3: McManus KJ, Hendzel MJ. CBP, a transcriptional coactivator and acetyltransferase Biochem Cell Biol. 2001;79(3):253-66.
4: Marschalek R. MLL leukemia and future treatment strategies Arch Pharm (Weinheim). 2015 Apr;348(4):221-8.
5: Troke PJ, Kindle KB, Collins HM, Heery DM. MOZ fusion proteins in acute myeloid leukaemia Biochem Soc Symp. 2006;(73):23-39.
6: Adamson AW, Ding YC, Steele L, Leong LA, Morgan R, Wakabayashi MT, Han ES, Dellinger TH, Lin PS, Hakim AA, Wilczynski S, Warden CD, Tao S, Bedell V, Cristea MC, Neuhausen SL. Genomic analyses of germline and somatic variation in high-grade serous ovarian cancer J Ovarian Res. 2023 Jul 17;16(1):141.
7: Feng D, Li Z, Yang L, Liang H, He H, Liu L, Zhang W. BMSC-EV-derived lncRNA NORAD Facilitates Migration, Invasion, and Angiogenesis in Osteosarcoma Cells by Regulating CREBBP via Delivery of miR-877-3p Oxid Med Cell Longev. 2022 Mar 1;2022:8825784.
8: Liedman D, Zeleznik-Le N. Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein Curr Opin Hematol. 2001 Jul;8(4):218-23.
9: Lakshmanan MD, Shaheer K. Endocrine disrupting chemicals may deregulate DNA repair through estrogen receptor mediated seizing of CBP/p300 acetylase J Endocrinol Invest. 2020 Sep;43(9):1189-1196.
10: Liu J, Zhao Z, Wei S, Li B, Zhao Z. Genomic features of Chinese small cell lung cancer BMC Med Genomics. 2022 May 20;15(1):117.

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