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A new interesting article has been published in J Clin Endocrinol Metab. 2019 Aug 5. pii: jc.2019-00365. doi: 10.1210/jc.2019-00365. and titled:

The steroid profile of adrenal incidentalomas: subtyping subjects with high cardiovascular risk.

Authors of this article are:

Di Dalmazi G, Fanelli F, Zavatta G, Ricci Bitti S, Mezzullo M, Repaci A, Pelusi C, Gambineri A, Altieri P, Mosconi C, Balacchi C, Golfieri R, Cosentino ER, Borghi C, Vicennati V, Pasquali R, Pagotto U.

A summary of the article is shown below:

CONTEXT: Steroid profiling by mass spectrometry (MS) has shown implication for diagnosis and subtyping of adrenal tumors.OBJECTIVES: To investigate steroid profiles and their cardiovascular correlates in a large cohort of patients with non-secreting (NS) adrenal incidentalomas and autonomous cortisol secretion (ACS).DESIGN: Cohort study.SETTING: University hospital.PATIENTS: Patients (n=302) with incidentally-discovered adrenal masses, divided into unilateral adenoma and hyperplasia with ACS (n=46 and n=52, respectively) and NS (n=120 and n=84, respectively). Post-dexamethasone suppression test (DST) cortisol below or above 50 nmol/L defined NS and ACS, respectively.INTERVENTION: Analysis of 10-steroid panel by liquid chromatography-tandem MS (LC-MS/MS) and clinical data (mean follow-up 39 months).MAIN OUTCOME MEASURES: Difference in baseline and post-DST steroid profiles among groups. Correlation with cardiovascular profile.RESULTS: Patients with unilateral adenomas and ACS showed higher cortisol, 11-deoxycortisol, and corticosterone, and lower dehydroepiandrosterone than NS adenomas. Patients with ACS hyperplasia showed higher cortisol and lower androgens in females than NS ones. Patients with ACS had reduced suppression of post-DST cortisol, 11-deoxycortisol, and corticosterone, irrespective of adrenal morphology. Post-DST cortisol and corticosterone were associated with higher prevalence of severe/resistant hypertension. Patients with ACS unilateral adenomas showed higher incidence of worsening of hypertensive disease and novel cardiovascular events than NS ones, with post-DST cortisol (Hazard Ratio [HR] 1.02, 95%CI 1.01-1.03, P<0.001) and baseline corticosterone (HR 1.06, 95%CI 1.01-1.12, P=0.031) among the main predictors.CONCLUSIONS: Patients with adrenal incidentalomas showed different steroid profiles, depending on functional status and adrenal morphology, with implications for their cardiovascular status.Copyright © 2019 Endocrine Society.
Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31381072 forceshot=true]

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